Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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I157515-25g | 25g | In stock | $23.90 | |
I157515-50g | 50g | In stock | $42.90 | |
I157515-100g | 100g | In stock | $47.90 | |
I157515-250g | 250g | In stock | $106.90 | |
I157515-500g | 500g | In stock | $160.90 |
Osmotic diuretic agent
Synonyms | 1,4:3,6-Dianhydro-D-sorbitol | 1,4:3,6-Dianhydrosorbitol | BIDD:GT0695 | NSC40725 | NSC-40725 | D-Glucitol, 1,4:3,6-dianhydro- | EN300-170910 | D00347 | Dianhydro-D-glucitol | 1,4-Dianhydrosorbitol | Isosorbida (INN-Spanish) | Tox21_111861 | Glucitol, 1,4 |
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Specifications & Purity | ≥98%(GC) |
Biochemical and Physiological Mechanisms | Osmotic diuretic agent. Nitric oxide donor. Shows vasodilatory, antihypertensive and diuretic effects in vivo. Orally active. |
Storage Temp | Argon charged |
Shipped In | Normal |
Note | 1g,50g卖完停产,不再备货。Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488181710 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488181710 |
IUPAC Name | (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol |
INCHI | InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1 |
InChi Key | KLDXJTOLSGUMSJ-JGWLITMVSA-N |
Canonical SMILES | C1C(C2C(O1)C(CO2)O)O |
Isomeric SMILES | C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O |
WGK Germany | 2 |
RTECS | LZ4380000 |
PubChem CID | 12597 |
Molecular Weight | 146.14 |
Beilstein | 80510 |
Reaxy-Rn | 80510 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2425376 | Certificate of Analysis | Mar 21, 2024 | I157515 |
D2425260 | Certificate of Analysis | Mar 21, 2024 | I157515 |
C23111280 | Certificate of Analysis | Jan 07, 2023 | I157515 |
K2420163 | Certificate of Analysis | Jan 07, 2023 | I157515 |
F2424520 | Certificate of Analysis | Jan 07, 2023 | I157515 |
F2404045 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C2405114 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111292 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111272 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111268 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111262 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111243 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111242 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111241 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111239 | Certificate of Analysis | Jan 07, 2023 | I157515 |
C23111260 | Certificate of Analysis | Jan 07, 2023 | I157515 |
G2213596 | Certificate of Analysis | Jul 20, 2022 | I157515 |
A2306230 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2405065 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222894 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222893 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222881 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222866 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222878 | Certificate of Analysis | Jun 27, 2022 | I157515 |
I2222879 | Certificate of Analysis | Jun 27, 2022 | I157515 |
C2215333 | Certificate of Analysis | Feb 12, 2022 | I157515 |
C2215453 | Certificate of Analysis | Feb 12, 2022 | I157515 |
C2215469 | Certificate of Analysis | Feb 12, 2022 | I157515 |
C2215487 | Certificate of Analysis | Feb 12, 2022 | I157515 |
C2215489 | Certificate of Analysis | Feb 12, 2022 | I157515 |
C2215490 | Certificate of Analysis | Feb 12, 2022 | I157515 |
Solubility | Soluble in alcohols, water and ketones. |
---|---|
Sensitivity | Moisture sensitive |
Specific Rotation[α] | 45° (C=5,H2O) |
Boil Point(°C) | 175°C/2mmHg |
Melt Point(°C) | 58-63℃ |
WGK Germany | 2 |
---|---|
RTECS | LZ4380000 |
Reaxy-Rn | 80510 |
Merck Index | 5224 |
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1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu. (2023) Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents. CHEMOSPHERE, 344 (15): (140371). [PMID:37820874] [10.1016/j.chemosphere.2023.140371] |
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing. (2023) Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings. Journal of Coatings Technology and Research, 20 (5): (1747-1758). [PMID:] [10.1007/s11998-023-00778-3] |
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao. (2023) Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide. CHEMICAL ENGINEERING JOURNAL, 460 (141780). [PMID:] [10.1016/j.cej.2023.141780] |
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu. (2023) Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance. FLAVOUR AND FRAGRANCE JOURNAL, 38 (2): (73-82). [PMID:] [10.1002/ffj.3727] |
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang. (2022) Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber. POLYMER, 258 (125313). [PMID:] [10.1016/j.polymer.2022.125313] |
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu. (2022) Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer. MACROMOLECULAR MATERIALS AND ENGINEERING, 307 (9): (2200203). [PMID:] [10.1002/mame.202200203] |
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu. (2021) Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide. Progress in Natural Science-Materials International, 31 (546). [PMID:] [10.1016/j.pnsc.2021.06.004] |
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu. (2021) Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites. INDUSTRIAL CROPS AND PRODUCTS, 170 (113744). [PMID:] [10.1016/j.indcrop.2021.113744] |
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu. (2021) A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains. GREEN CHEMISTRY, 23 (11): (4134-4143). [PMID:] [10.1039/D1GC01150B] |
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang. (2021) Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study. GREEN CHEMISTRY, 23 (3): (1353-1360). [PMID:] [10.1039/D0GC03745A] |
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang. (2020) Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate. ACS Sustainable Chemistry & Engineering, 8 (27): (9968–9979). [PMID:] [10.1021/acssuschemeng.0c00430] |
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang. (2020) High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes. BIORESOURCE TECHNOLOGY, 297 (122492). [PMID:31796376] [10.1016/j.biortech.2019.122492] |
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu. (2019) A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide. ACS Applied Polymer Materials, 1 (9): (2313–2321). [PMID:] [10.1021/acsapm.9b00332] |
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao. (2019) Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid. APPLIED CATALYSIS B-ENVIRONMENTAL, 240 (182). [PMID:] [10.1016/j.apcatb.2018.08.036] |
1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu. (2023) Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents. CHEMOSPHERE, 344 (15): (140371). [PMID:37820874] [10.1016/j.chemosphere.2023.140371] |
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing. (2023) Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings. Journal of Coatings Technology and Research, 20 (5): (1747-1758). [PMID:] [10.1007/s11998-023-00778-3] |
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao. (2023) Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide. CHEMICAL ENGINEERING JOURNAL, 460 (141780). [PMID:] [10.1016/j.cej.2023.141780] |
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu. (2023) Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance. FLAVOUR AND FRAGRANCE JOURNAL, 38 (2): (73-82). [PMID:] [10.1002/ffj.3727] |
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang. (2022) Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber. POLYMER, 258 (125313). [PMID:] [10.1016/j.polymer.2022.125313] |
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu. (2022) Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer. MACROMOLECULAR MATERIALS AND ENGINEERING, 307 (9): (2200203). [PMID:] [10.1002/mame.202200203] |
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu. (2021) Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide. Progress in Natural Science-Materials International, 31 (546). [PMID:] [10.1016/j.pnsc.2021.06.004] |
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu. (2021) Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites. INDUSTRIAL CROPS AND PRODUCTS, 170 (113744). [PMID:] [10.1016/j.indcrop.2021.113744] |
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu. (2021) A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains. GREEN CHEMISTRY, 23 (11): (4134-4143). [PMID:] [10.1039/D1GC01150B] |
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang. (2021) Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study. GREEN CHEMISTRY, 23 (3): (1353-1360). [PMID:] [10.1039/D0GC03745A] |
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang. (2020) Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate. ACS Sustainable Chemistry & Engineering, 8 (27): (9968–9979). [PMID:] [10.1021/acssuschemeng.0c00430] |
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang. (2020) High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes. BIORESOURCE TECHNOLOGY, 297 (122492). [PMID:31796376] [10.1016/j.biortech.2019.122492] |
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu. (2019) A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide. ACS Applied Polymer Materials, 1 (9): (2313–2321). [PMID:] [10.1021/acsapm.9b00332] |
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao. (2019) Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid. APPLIED CATALYSIS B-ENVIRONMENTAL, 240 (182). [PMID:] [10.1016/j.apcatb.2018.08.036] |