Isosorbide - >98.0%(GC), high purity , CAS No.652-67-5

  • ≥98%(GC)
Item Number
I157515
Grouped product items
SKUSizeAvailabilityPrice Qty
I157515-25g
25g
In stock
$23.90
I157515-50g
50g
In stock
$42.90
I157515-100g
100g
In stock
$47.90
I157515-250g
250g
In stock
$106.90
I157515-500g
500g
In stock
$160.90

Osmotic diuretic agent

Basic Description

Synonyms1,4:3,6-Dianhydro-D-sorbitol | 1,4:3,6-Dianhydrosorbitol | BIDD:GT0695 | NSC40725 | NSC-40725 | D-Glucitol, 1,4:3,6-dianhydro- | EN300-170910 | D00347 | Dianhydro-D-glucitol | 1,4-Dianhydrosorbitol | Isosorbida (INN-Spanish) | Tox21_111861 | Glucitol, 1,4
Specifications & Purity≥98%(GC)
Biochemical and Physiological MechanismsOsmotic diuretic agent. Nitric oxide donor. Shows vasodilatory, antihypertensive and diuretic effects in vivo. Orally active.
Storage TempArgon charged
Shipped InNormal
Note1g,50g卖完停产,不再备货。Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488181710
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181710
IUPAC Name (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
INCHI InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
InChi Key KLDXJTOLSGUMSJ-JGWLITMVSA-N
Canonical SMILES C1C(C2C(O1)C(CO2)O)O
Isomeric SMILES C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
WGK Germany 2
RTECS LZ4380000
PubChem CID 12597
Molecular Weight 146.14
Beilstein 80510
Reaxy-Rn 80510

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot NumberCertificate TypeDateItem
D2425376Certificate of AnalysisMar 21, 2024 I157515
D2425260Certificate of AnalysisMar 21, 2024 I157515
C23111280Certificate of AnalysisJan 07, 2023 I157515
K2420163Certificate of AnalysisJan 07, 2023 I157515
F2424520Certificate of AnalysisJan 07, 2023 I157515
F2404045Certificate of AnalysisJan 07, 2023 I157515
C2405114Certificate of AnalysisJan 07, 2023 I157515
C23111292Certificate of AnalysisJan 07, 2023 I157515
C23111272Certificate of AnalysisJan 07, 2023 I157515
C23111268Certificate of AnalysisJan 07, 2023 I157515
C23111262Certificate of AnalysisJan 07, 2023 I157515
C23111243Certificate of AnalysisJan 07, 2023 I157515
C23111242Certificate of AnalysisJan 07, 2023 I157515
C23111241Certificate of AnalysisJan 07, 2023 I157515
C23111239Certificate of AnalysisJan 07, 2023 I157515
C23111260Certificate of AnalysisJan 07, 2023 I157515
G2213596Certificate of AnalysisJul 20, 2022 I157515
A2306230Certificate of AnalysisJun 27, 2022 I157515
I2405065Certificate of AnalysisJun 27, 2022 I157515
I2222894Certificate of AnalysisJun 27, 2022 I157515
I2222893Certificate of AnalysisJun 27, 2022 I157515
I2222881Certificate of AnalysisJun 27, 2022 I157515
I2222866Certificate of AnalysisJun 27, 2022 I157515
I2222878Certificate of AnalysisJun 27, 2022 I157515
I2222879Certificate of AnalysisJun 27, 2022 I157515
C2215333Certificate of AnalysisFeb 12, 2022 I157515
C2215453Certificate of AnalysisFeb 12, 2022 I157515
C2215469Certificate of AnalysisFeb 12, 2022 I157515
C2215487Certificate of AnalysisFeb 12, 2022 I157515
C2215489Certificate of AnalysisFeb 12, 2022 I157515
C2215490Certificate of AnalysisFeb 12, 2022 I157515

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Chemical and Physical Properties

SolubilitySoluble in alcohols, water and ketones.
SensitivityMoisture sensitive
Specific Rotation[α]45° (C=5,H2O)
Boil Point(°C)175°C/2mmHg
Melt Point(°C)58-63℃

Safety and Hazards(GHS)

WGK Germany 2
RTECS LZ4380000
Reaxy-Rn 80510
Merck Index 5224

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Citations of This Product

1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu.  (2023)  Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents.  CHEMOSPHERE,  344  (15): (140371).  [PMID:37820874] [10.1016/j.chemosphere.2023.140371]
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing.  (2023)  Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings.  Journal of Coatings Technology and Research,  20  (5): (1747-1758).  [PMID:] [10.1007/s11998-023-00778-3]
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao.  (2023)  Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide.  CHEMICAL ENGINEERING JOURNAL,  460  (141780).  [PMID:] [10.1016/j.cej.2023.141780]
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu.  (2023)  Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance.  FLAVOUR AND FRAGRANCE JOURNAL,  38  (2): (73-82).  [PMID:] [10.1002/ffj.3727]
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang.  (2022)  Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber.  POLYMER,  258  (125313).  [PMID:] [10.1016/j.polymer.2022.125313]
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu.  (2022)  Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer.  MACROMOLECULAR MATERIALS AND ENGINEERING,  307  (9): (2200203).  [PMID:] [10.1002/mame.202200203]
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu.  (2021)  Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide.  Progress in Natural Science-Materials International,  31  (546).  [PMID:] [10.1016/j.pnsc.2021.06.004]
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu.  (2021)  Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites.  INDUSTRIAL CROPS AND PRODUCTS,  170  (113744).  [PMID:] [10.1016/j.indcrop.2021.113744]
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu.  (2021)  A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains.  GREEN CHEMISTRY,  23  (11): (4134-4143).  [PMID:] [10.1039/D1GC01150B]
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang.  (2021)  Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study.  GREEN CHEMISTRY,  23  (3): (1353-1360).  [PMID:] [10.1039/D0GC03745A]
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang.  (2020)  Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate.  ACS Sustainable Chemistry & Engineering,  (27): (9968–9979).  [PMID:] [10.1021/acssuschemeng.0c00430]
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang.  (2020)  High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes.  BIORESOURCE TECHNOLOGY,  297  (122492).  [PMID:31796376] [10.1016/j.biortech.2019.122492]
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu.  (2019)  A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide.  ACS Applied Polymer Materials,  (9): (2313–2321).  [PMID:] [10.1021/acsapm.9b00332]
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao.  (2019)  Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid.  APPLIED CATALYSIS B-ENVIRONMENTAL,  240  (182).  [PMID:] [10.1016/j.apcatb.2018.08.036]

References

1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu.  (2023)  Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents.  CHEMOSPHERE,  344  (15): (140371).  [PMID:37820874] [10.1016/j.chemosphere.2023.140371]
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing.  (2023)  Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings.  Journal of Coatings Technology and Research,  20  (5): (1747-1758).  [PMID:] [10.1007/s11998-023-00778-3]
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao.  (2023)  Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide.  CHEMICAL ENGINEERING JOURNAL,  460  (141780).  [PMID:] [10.1016/j.cej.2023.141780]
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu.  (2023)  Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance.  FLAVOUR AND FRAGRANCE JOURNAL,  38  (2): (73-82).  [PMID:] [10.1002/ffj.3727]
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang.  (2022)  Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber.  POLYMER,  258  (125313).  [PMID:] [10.1016/j.polymer.2022.125313]
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu.  (2022)  Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer.  MACROMOLECULAR MATERIALS AND ENGINEERING,  307  (9): (2200203).  [PMID:] [10.1002/mame.202200203]
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu.  (2021)  Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide.  Progress in Natural Science-Materials International,  31  (546).  [PMID:] [10.1016/j.pnsc.2021.06.004]
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu.  (2021)  Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites.  INDUSTRIAL CROPS AND PRODUCTS,  170  (113744).  [PMID:] [10.1016/j.indcrop.2021.113744]
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu.  (2021)  A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains.  GREEN CHEMISTRY,  23  (11): (4134-4143).  [PMID:] [10.1039/D1GC01150B]
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang.  (2021)  Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study.  GREEN CHEMISTRY,  23  (3): (1353-1360).  [PMID:] [10.1039/D0GC03745A]
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang.  (2020)  Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate.  ACS Sustainable Chemistry & Engineering,  (27): (9968–9979).  [PMID:] [10.1021/acssuschemeng.0c00430]
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang.  (2020)  High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes.  BIORESOURCE TECHNOLOGY,  297  (122492).  [PMID:31796376] [10.1016/j.biortech.2019.122492]
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu.  (2019)  A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide.  ACS Applied Polymer Materials,  (9): (2313–2321).  [PMID:] [10.1021/acsapm.9b00332]
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao.  (2019)  Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid.  APPLIED CATALYSIS B-ENVIRONMENTAL,  240  (182).  [PMID:] [10.1016/j.apcatb.2018.08.036]

Solution Calculators