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Isradipine - >98.0%(HPLC), high purity , CAS No.75695-93-1, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4

Item Number
I157715
Grouped product items
SKUSizeAvailabilityPrice Qty
I157715-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$26.90
I157715-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$110.90
I157715-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$367.90
I157715-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$828.90
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L-type Ca 2+ channel blocker

View related series
Calcium Channel Cav1.2 Gating inhibitor Cav1.3 Gating inhibitor Cav1.4 Gating inhibitor Membrane Transporter/Ion Channel Neuronal Signaling

Basic Description

Synonyms3-isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | DynaCirc | ISOPROPYL METHYL (+/-)-4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE | Lomir | PN 200-110 | GTPL4488 | KBioSS_
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsL-type Ca 2+ channel blocker.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeGATING INHIBITOR
Mechanism of actionGating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates
Isradipine has been used to explore neuroprotective activity.

Associated Targets(Human)

CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
INCHI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChi Key HMJIYCCIJYRONP-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
Isomeric SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
WGK Germany 3
PubChem CID 3784
Molecular Weight 371.39

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
F1927090Certificate of AnalysisApr 13, 2023 I157715

Chemical and Physical Properties

SensitivityHeat sensitive
Melt Point(°C)169 °C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS09,   GHS07
Signal Danger
Hazard Statements

H319:Causes serious eye irritation

H301:Toxic if swallowed

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

H372:Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Merck Index 5240

Related Documents

 SDS

 Specification Sheet

References

1. Jurkovicová-Tarabová B et al..  (2012)  Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice..  J Neurophysiol,  108  (2): (365-79).  [PMID:22539826]
2. Díaz-García CM et al..  (2021)  The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle..  Elife,  10    [PMID:33555254]
3. Meyer DJ et al..  (2022)  The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells..  Elife,  11    [PMID:36222651]

Solution Calculators

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