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Isradipine - >98.0%(HPLC), high purity , CAS No.75695-93-1, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4

Specifications & Purity: >98.0%(HPLC)

CAS#: 75695-93-1
Formula: C₁₉H₂₁N₃O₅
Molecular Weight: 371.39
MDL number: MFCD00153820
PubChem CID: 3784

Item Number

I157715

Grouped product items
SKU	Size	Availability	Price
I157715-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$26.90
I157715-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$110.90
I157715-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$367.90
I157715-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$828.90

L-type Ca 2+ channel blocker

View related series

Cav1.2 Gating inhibitor Cav1.3 Gating inhibitor Cav1.4 Gating inhibitor

Basic Description

Synonyms	isradipine\|75695-93-1\|DynaCirc\|Isradipin\|Prescal\|Lomir\|Isrodipine\|Dynacirc CR\|Esradin\|Clivoten\|PN 200-110\|Dynacrine\|Isradipinum [Latin]\|Isradipino [Spanish]\|PN-200-110\|Isradipino\|Isradipinum\|Rebriden\|(+-)-Isradipine\|DynaCire\|DynaCire CR\|PN 200\|(+/-)-Israd
Specifications & Purity	>98.0%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	GATING INHIBITOR
Mechanism of action	Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4

Associated Targets

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 4 Activities

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D 1 Activities

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F 1 Activities

Discover Target: CACNA1F

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
INCHI	InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChi Key	HMJIYCCIJYRONP-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
Isomeric SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
WGK Germany	3
PubChem CID	3784
Molecular Weight	371.39

DrugBank Ligand

CAS Registry No.

Wikipedia

PubChem CID

ChEMBL Ligand

PEP

DrugCentral Ligand

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1 results found

Lot Number	Certificate Type	Date	Item
F1927090	Certificate of Analysis	Apr 13, 2023	I157715

Sensitivity

Heat sensitive

Melt Point(°C)

169 °C

Pictogram(s)

GHS06,GHS08,GHS09,GHS07

Signal

Danger

Hazard Statements

H319,H301,H400,H410,H372

Precautionary Statements

P305+P351+P338,P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P264+P265,P301+P316,P337+P317,P319

WGK Germany

Merck Index

5240

References

1. Jurkovicová-Tarabová B et al.. (2012) Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice.. J Neurophysiol, 108 (2): (365-79). [PMID:22539826]
2. Díaz-García CM et al.. (2021) The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle.. Elife, 10 [PMID:33555254]
3. Meyer DJ et al.. (2022) The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells.. Elife, 11 [PMID:36222651]

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Isradipine - >98.0%(HPLC), high purity , CAS No.75695-93-1, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4

Basic Description

Associated Targets

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 4 Activities

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D 1 Activities

CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F 1 Activities

Names and Identifiers

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Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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