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ISRIB - 98%, high purity , CAS No.548470-11-7
Basic Description Synonyms ISRIB | ISRIB trans-isomer | BCP23947 | ISRIB, >=98% (HPLC) | N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) | N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] | A897811 | N,N'-(cis-Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetam Specifications & Purity ≥98% Biochemical and Physiological Mechanisms ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Targets
ISR ; eIF2α
Product Properties ALogP 4.055 HBD Count 2 Rotatable Bond 8
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide INCHI InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28) InChi Key HJGMCDHQPXTGAV-UHFFFAOYSA-N Canonical SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl Isomeric SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl PubChem CID 1011240 Molecular Weight 451.34
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 10 mg/mL (22.15 mM); Water: Insoluble; Ethanol: Insoluble; DMSO(mg / mL) Max Solubility 10 DMSO(mM) Max Solubility 22.1562458457039 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
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G2226499