Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

ISRIB (trans-isomer) - ≥96%, high purity , CAS No.1597403-47-8

  • ≥96%
Item Number
I275318
Grouped product items
SKUSizeAvailabilityPrice Qty
I275318-5mg
5mg
In stock
$161.90
I275318-10mg
10mg
In stock
$268.90
I275318-25mg
25mg
In stock
$605.90
I275318-50mg
50mg
In stock
$891.90
I275318-100mg
100mg
In stock
$1,611.90
I275318-250mg
250mg
In stock
$3,627.90
I275318-1g
1g
In stock
$13,057.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Potent and selective\xa0PERK\xa0inhibitor

Basic Description

SynonymsISRIB | ISRIB trans-isomer | BCP23947 | ISRIB, >=98% (HPLC) | N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) | N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] | A897811 | N,N'-(cis-Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetam
Specifications & Purity≥96%
Biochemical and Physiological MechanismsPotent and selective\xa0PERK\xa0inhibitor with\xa0IC 50 of 5 nM. Integrated stress response (ISR) inhibitor.SRIB is a blood-brain barrier penetrant and a potent selective integrated stress response (ISR) inhibitor of impaired adaptation to endoplasmic ret
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteRefer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Shipped at room temperature. Store at -20°C.

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
INCHI InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChi Key HJGMCDHQPXTGAV-UHFFFAOYSA-N
Canonical SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
Isomeric SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
PubChem CID 1011240
Molecular Weight 451.34

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
L22071034Certificate of AnalysisSep 21, 2023 I275318
L2207758Certificate of AnalysisSep 21, 2023 I275318
L2207759Certificate of AnalysisSep 21, 2023 I275318
L2207760Certificate of AnalysisSep 21, 2023 I275318
L2207761Certificate of AnalysisSep 21, 2023 I275318
L2207762Certificate of AnalysisSep 21, 2023 I275318
L2207763Certificate of AnalysisSep 21, 2023 I275318

Chemical and Physical Properties

SolubilitySoluble in DMSO to 10 mM with gentle warming

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. ISRIB - 98%, used for , CAS No. 548470-11-7, by Aladdin Scientific
    ISRIB
    • ≥98%

    Starting at $103.90

  2. ISRIB - 10mM in DMSO, used for , CAS No. 548470-11-7, by Aladdin Scientific
    ISRIB
    • 10mM in DMSO

    Starting at $125.90

  3. ISRIB (trans-isomer) - 2mM in DMSO, used for , CAS No. 1597403-47-8, by Aladdin Scientific
    ISRIB (trans-isomer)
    • 2mM in DMSO

    Starting at $103.90

References

1. Hinnebusch AG.  (2015)  Cell biology. Blocking stress response for better memory?.  Science,  348  (6238): (967-8).  [PMID:26023119]
2. Sidrauski C et al..  (2013)  Pharmacological brake-release of mRNA translation enhances cognitive memory..  Elife,  2  (e00498).  [PMID:23741617]
3. Sekine Y et al..  (2015)  Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound..  Science,  348  (6238): (1027-30).  [PMID:25858979]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.