ISRIB (trans-isomer) - 2mM in DMSO, high purity , CAS No.1597403-47-8

Item Number

I421913

Grouped product items
SKU	Size	Availability	Price	Qty
I421913-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$103.90

Potent and selective\xa0PERK\xa0inhibitor

Basic Description

Synonyms	ISRIB \| trans-ISRIB \| 1597403-47-8 \| 548470-11-7 \| ISRIB (trans-isomer) \| N,N'-(cis-Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) \| 1597403-48-9 \| 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide \| N,N'-(Cyclohexane-1,4-diyl)bis(2-
Specifications & Purity	2mM in DMSO
Biochemical and Physiological Mechanisms	Potent and selective\xa0PERK\xa0inhibitor with\xa0IC 50 of 5 nM. Integrated stress response (ISR) inhibitor.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
INCHI	InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChi Key	HJGMCDHQPXTGAV-UHFFFAOYSA-N
Canonical SMILES	C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
Isomeric SMILES	C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
PubChem CID	1011240
Molecular Weight	451.34

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Basic Description