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Itacitinib (INCB39110) - 97%, high purity , CAS No.1334298-90-6, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2

Item Number
I413838
Grouped product items
SKUSizeAvailabilityPrice Qty
I413838-5mg
5mg
In stock
$137.90
I413838-10mg
10mg
In stock
$226.90
I413838-25mg
25mg
In stock
$510.90
I413838-50mg
50mg
In stock
$682.90
I413838-100mg
100mg
In stock
$1,088.90
I413838-250mg
250mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$2,450.90
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JAK Inhibitors

View related series
Epigenetics JAK JAK/STAT Signaling Janus kinase 1 Inhibitor Janus kinase 2 Inhibitor Protein Tyrosine Kinase/RTK Stem Cell/Wnt

Basic Description

Synonyms1334298-90-6 | Itacitinib (USAN/INN) | Itacitinib | BCP13794 | 1651228-00-0 | 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile | HY-W018392 | 19J3781LPM
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsItacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Janus kinase 1;Inhibitor of Janus kinase 2

Product Properties

ALogP1.6

Associated Targets(Human)

JAK1 Tclin Tyrosine-protein kinase JAK1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
JAK2 Tclin Tyrosine-protein kinase JAK2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYK2 Tclin Tyrosine-protein kinase TYK2 (5029 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488201587
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488201587
IUPAC Name 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
INCHI InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
InChi Key KTBSXLIQKWEBRB-UHFFFAOYSA-N
Canonical SMILES C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F
Isomeric SMILES C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F
Alternate CAS 1651228-00-0,1334298-90-6
PubChem CID 53380437
MeSH Entry Terms (1-(1-(3-Fluoro-2-(trifluoromethyl)isonicotinoyl)-4-piperidinyl)-3-(4-(1H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-azetidinyl)acetonitrile;itacitinib
Molecular Weight 553.51

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
D23181000Certificate of AnalysisApr 03, 2023 I413838
D23181008Certificate of AnalysisApr 03, 2023 I413838
D23181011Certificate of AnalysisApr 03, 2023 I413838
D23181018Certificate of AnalysisApr 03, 2023 I413838
D23181067Certificate of AnalysisApr 03, 2023 I413838
D23181068Certificate of AnalysisApr 03, 2023 I413838
D23181074Certificate of AnalysisApr 03, 2023 I413838
D23181075Certificate of AnalysisApr 03, 2023 I413838
D23181081Certificate of AnalysisApr 03, 2023 I413838
D23181082Certificate of AnalysisApr 03, 2023 I413838
D2318995Certificate of AnalysisApr 03, 2023 I413838
D2318996Certificate of AnalysisApr 03, 2023 I413838

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL (180.66 mM); Ethanol: 100 mg/mL (180.66 mM); Water: Insoluble;

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Itacitinib (INCB39110) - 10mM in DMSO, used for , CAS No. 1334298-90-6, by Aladdin Scientific
    Itacitinib (INCB39110)

    Starting at $241.90

Solution Calculators

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