JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Targets
Ligand-gated ion channels
P2X receptors
ITH15004 , CAS No.2600675-12-3, Antagonist of P2X7

Skip to the end of the images gallery

Skip to the beginning of the images gallery

ITH15004 , CAS No.2600675-12-3, Antagonist of P2X7

Moligand™

CAS#: 2600675-12-3
PubChem CID: 162651518

Item Number

I611202

Grouped product items
SKU	Size	Availability	Price	Qty
I611202-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$280.90
I611202-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$955.90

View related series

P2X7 Antagonist

Basic Description

Synonyms	compound 6;ITH-15004
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2X7

Associated Targets(Human)

P2RX7 Tchem P2X purinoceptor 7 (1 Activities)

Discover Target: P2RX7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX4 Tchem P2X purinoceptor 4 (516 Activities)

Discover Target: P2RX4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RX7 Tchem P2X purinoceptor 7 (5534 Activities)

Discover Target: P2RX7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RX1 Tchem P2X purinoceptor 1 (328 Activities)

Discover Target: P2RX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)

Discover Target: P2rx2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)-1-ethanone
INCHI	InChI=1S/C13H7Cl3N4O/c14-7-1-2-8(9(15)3-7)10(21)4-20-6-19-11-12(16)17-5-18-13(11)20/h1-3,5-6H,4H2
InChi Key	NLRGSGVPLHCTPK-UHFFFAOYSA-N
Canonical SMILES	Clc1c2ncn(c2ncn1)CC(=O)c1c(cc(cc1)Cl)Cl
Isomeric SMILES	C1=CC(=C(C=C1Cl)Cl)C(=O)CN2C=NC3=C2N=CN=C3Cl
PubChem CID	162651518

Database links

CAS Registry No.	2600675-12-3
PubChem CID	162651518

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C. (2021) Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation.. J Med Chem, 64 (4): (2272-2290). [PMID:33560845] [10.1021/acs.jmedchem.0c02145]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.