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IU1 - 10mM in DMSO, high purity , CAS No.314245-33-5
Selective, reversible Usp14 inhibitor. Cell-permeable
Basic Description Synonyms 314245-33-5 | IU1 | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one | 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone | 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone | 1-(1-( Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Selective, reversible Usp14 inhibitor (IC 50 = 4 μM). Enhances degradation of proteasome substrates. Reduces rate of ubiquitin chain trimming bound to cyclin B or other ubiquitin chains. Active in vitro . Cell-permeable. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone INCHI InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 InChi Key JUWDSDKJBMFLHE-UHFFFAOYSA-N Canonical SMILES CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3 Isomeric SMILES CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3 WGK Germany 3 PubChem CID 675434 Molecular Weight 300.37
Safety and Hazards(GHS) Pictogram(s) GHS05 Signal Danger Hazard Statements H318: Causes serious eye damage
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
WGK Germany 3
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