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ivabradine , Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker, CAS No.155974-00-8, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker
Basic Description Synonyms Ivabradine|155974-00-8|S-16257|UNII-3H48L0LPZQ|3H48L0LPZQ|S 16257|CHEBI:85966|S 16257-2|CHEMBL471737|DTXSID2048240|(S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-o Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type BLOCKER, CHANNEL BLOCKER Mechanism of action Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker
Names and Identifiers IUPAC Name 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one INCHI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1 InChi Key ACRHBAYQBXXRTO-OAQYLSRUSA-N Canonical SMILES CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC Isomeric SMILES CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC Alternate CAS 155974-00-8；148849-67-6 PubChem CID 132999 MeSH Entry Terms 7,8-dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one;Corlanor;ivabradine;S 16257;S 16257 2;S 16257-2;S 162572;S 16260 2;S 16260-2;S 162602;S-16257;S-16257-2;S-16260-2;S16257;S162572;S162 Molecular Weight 468.59
Chemical and Physical Properties Sensitivity Moisture sensitive
References 1. DiFrancesco D, Camm JA. (2004) Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.. Drugs, 64 (16): (1757-65). [PMID:15301560 ] 2. Mar PL, Raj SR. (2020) Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.. Annu Rev Med, 71 (3): (235-248). [PMID:31412221 ]
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