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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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I288087-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $444.90 | |
I288087-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $801.90 | |
I288087-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,802.90 | |
I288087-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,244.90 |
Potent PORCN inhibitor; activein vivo
Synonyms | IWP-12 ;2-((3,6-dimethyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylbenzo[d]thiazol-2-yl)acetamide;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50= 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regenerationin vivo. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Product Describtion: IWP-12 is a potent inhibitor of porcupine (PORCN) and inhibits cell-autono mous Wnt signaling with an IC50 of 15 nM. |
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IUPAC Name | 2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
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INCHI | InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23) |
InChi Key | RBFDSBJDWZOTGR-UHFFFAOYSA-N |
Canonical SMILES | CC1CC2=C(S1)C(=O)N(C(=N2)SCC(=O)NC3=NC4=C(S3)C=C(C=C4)C)C |
Isomeric SMILES | CC1CC2=C(S1)C(=O)N(C(=N2)SCC(=O)NC3=NC4=C(S3)C=C(C=C4)C)C |
WGK Germany | 3 |
PubChem CID | 3244448 |
Molecular Weight | 418.56 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 41.86, Max Conc. mM: 100 |
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WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |