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IWP 4 - ≥98%(HPLC), high purity , CAS No.686772-17-8
Potent inhibitor of Wnt/β-catenin signaling
Basic Description Synonyms 686772-17-8 | IWP-4 | IWP 4 | 2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide | wnt inhibitor iwp-4 | CHEMBL1257090 | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)- Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent inhibitor of Wnt/β-catenin signaling (IC50= 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs. Storage Temp Store at 2-8°C Shipped In Wet ice
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide INCHI InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28) InChi Key RHUJMHOIQBDFQR-UHFFFAOYSA-N Canonical SMILES CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5OC)SCC4 Isomeric SMILES CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5OC)SCC4 PubChem CID 2155264 Molecular Weight 496.62
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 0.5, Max Conc. mM: 1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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