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IWR-1 - ≥98%, high purity , CAS No.1127442-82-3 1 Citations
Wnt/β-catenin signaling inhibitor; axin stabilizer
Basic Description Synonyms IWR1;4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide;rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotesβ-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cellsNegative Controlalso availa Storage Temp Room temperature Shipped In Normal
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-[(1S,2R,6S,7R)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide INCHI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+ InChi Key ZGSXEXBYLJIOGF-ALFLXDJESA-N Canonical SMILES C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6 Isomeric SMILES C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6 PubChem CID 44483163 Molecular Weight 409.44
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 40.94, Max Conc. mM: 100
Citations of This Product 1. Chen Min, Huang Shanjiao, Weng Shuoyun, Weng Junting, Guo Rongjie, Shi Bingbing, Liu Danjuan. (2023) Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, (1-13). [PMID:38133657 ]
References 1. Chen Min, Huang Shanjiao, Weng Shuoyun, Weng Junting, Guo Rongjie, Shi Bingbing, Liu Danjuan. (2023) Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, (1-13). [PMID:38133657 ]
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