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SKU | Size | Availability | Price | Qty |
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J422462-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Synonyms | JANEX-1 | 202475-60-3 | WHI-P131 | jak3 inhibitor i | Janex 1 | 4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | 4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol | 1J8Q49TR3I | CHEMBL405130 | 4-[(6,7-Dimethoxy-4-quinazolinyl)amino]ph |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 μM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation. |
ALogP | 3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol |
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INCHI | InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19) |
InChi Key | HOZUXBLMYUPGPZ-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC |
Isomeric SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC |
PubChem CID | 3794 |
Molecular Weight | 297.31 |
Enter Lot Number to search for COA:
Refractive Index | 1.69 |
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Boil Point(°C) | 468.10° C |
Melt Point(°C) | 192.17°C |