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J132593-100μg

100μg

Available within 4-8 weeks(?)

$1,038.90

Basic Description

Synonyms	jasplakinolide \| Jaspamide \| 102396-24-7 \| CHEBI:66104 \| (4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone \| beta-Alanine, N-(2-bromo-N-(N-(8-hydroxy
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.

Associated Targets(Human)

A498 (42825 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA46 (271 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAKI-1 (44928 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF-CEM (65223 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COLO 205 (50209 Activities)

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DLD-1 (17511 Activities)

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DMS-273 (14108 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

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HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

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KM12 (47707 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

M14 (47487 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-4 (44535 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-5 (45555 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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RXF 631 (11415 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNB-19 (46794 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNB-78 (14240 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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XF498 (12972 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HFF (3142 Activities)

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HOP-18 (11577 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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Associated Targets(non-human)

Candida albicans (78123 Activities)

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Toxoplasma gondii (4585 Activities)

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Oryctolagus cuniculus (11301 Activities)

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A10 (235 Activities)

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P388 (20296 Activities)

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ACT1 Actin (7 Activities)

Discover Target: ACT1

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Names and Identifiers

IUPAC Name	(4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
INCHI	InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
InChi Key	GQWYWHOHRVVHAP-DHKPLNAMSA-N
Canonical SMILES	CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
Isomeric SMILES	C[C@@H]\1C[C@@H](OC(=O)C[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@H](C/C(=C1)/C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
WGK Germany	3
RTECS	GX7000000
PubChem CID	9831636
Molecular Weight	709.67

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
K2110611	Certificate of Analysis	Aug 16, 2023	J132593
B2321806	Certificate of Analysis	Jan 02, 2023	J132593

Chemical and Physical Properties

Solubility	Soluble in DMSO (>2 mg/ml), water (partly), 100% ethanol, and 83% methanol
Sensitivity	Light sensitive

Safety and Hazards(GHS)

WGK Germany	3
RTECS	GX7000000

References

1. Xing B et al.. (2019) GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in ß cells.. J Cell Biol, 218 (3): (855-870). [PMID:30792230]
2. Alarcon-Martinez L et al.. (2018) Capillary pericytes express a-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection.. Elife, 7 [PMID:29561727]
3. Kepser LJ et al.. (2021) Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.. Sci Rep, 11 (4789). [PMID:33637797]
4. Hu J et al.. (2019) Distinct roles of two myosins in C. elegans spermatid differentiation.. PLoS Biol, 17 (4): (e3000211). [PMID:30990821]
5. Zheng Z et al.. (2020) NR4A1 promotes TNF-a-induced chondrocyte death and migration injury via activating the\xa0AMPK/Drp1/mitochondrial fission pathway.. Int J Mol Med, 45 (151-161). [PMID:31746366]
6. Nie Y et al.. (2021) Rearrangement of Actin Cytoskeleton by Zika Virus Infection Facilitates Blood-Testis Barrier Hyperpermeability.. Virol Sin, 36 (4): (692-705). [PMID:33534087]
7. Lin WF et al.. (2018) Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.. Mol Carcinog, 57 (7): (911-925). [PMID:29573464]
8. Yeung ML et al.. (2021) Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.. Cell, 184 (8): (2212-2228.e12). [PMID:33713620]
9. Wang G et al.. (2019) Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.. Elife, 8 [PMID:31042147]
10. Shi C et al.. (2018) Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways.. Redox Biol, 14 (59-71). [PMID:28869833]

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Jasplakinolide - ≥97% (HPLC), high purity , CAS No.102396-24-7