Jatrorrhizine - analytical standard,>97%(HPLC), high purity , CAS No.3621-38-3

Item Number
J101538
Grouped product items
SKUSizeAvailabilityPrice Qty
J101538-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
J101538-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$117.90
J101538-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$377.90

Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.

Basic Description

SynonymsFT-0686648 | jateorrhizine | Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy- (8CI) | Ethynyldimethylcarbinol | Trichloroethylsilicon | CHEBI:6087 | 2,2,2-Trichloro-1-ethanol | A-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium | NSC645313
Specifications & Purityanalytical standard, ≥97%(HPLC)
Biochemical and Physiological MechanismsNovel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb Rhizoma Coptidis. Protects neuronal-like cells against H 2 O 2 -induced toxicity. Protects against okadaic acid induced oxidative toxicity through inhibiting the Mitogen-acti
Storage TempStore at 2-8°C
Shipped InWet ice
Gradeanalytical standard
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HaCaT (4069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C2C12 (756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium sp. (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Large T antigen (1457 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATP-dependent molecular chaperone HSP82 (2186 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
vpr Aberrant vpr protein (14595 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
INCHI InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
InChi Key MXTLAHSTUOXGQF-UHFFFAOYSA-O
Canonical SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
Isomeric SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
PubChem CID 72323
Molecular Weight 355.38

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
F2117162Certificate of AnalysisApr 02, 2024 J101538
B2303382Certificate of AnalysisNov 12, 2022 J101538
B2303445Certificate of AnalysisNov 12, 2022 J101538
E2409035Certificate of AnalysisNov 12, 2022 J101538
J2327246Certificate of AnalysisNov 12, 2022 J101538

Related Documents

Citations of This Product

1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei.  (2023)  Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids.  MICROCHIMICA ACTA,  190  (12): (1-12).  [PMID:37999777] [10.1007/s00604-023-06053-x]
2. Longlong Gao, Rui Tian, Yong Shao.  (2023)  Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site.  Chemistry-Switzerland,  (3): (1497-1507).  [PMID:] [10.3390/chemistry5030102]
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]
4. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang.  (2020)  The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance.  NEW JOURNAL OF CHEMISTRY,  44  (27): (11704-11709).  [PMID:] [10.1039/D0NJ01197E]
5. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou.  (2018)  Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study.  MOLECULES,  23  (4): (714).  [PMID:29561801] [10.3390/molecules23040714]
6. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin.  (2017)  An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS.  MICROCHIMICA ACTA,  184  (8): (2715-2721).  [PMID:] [10.1007/s00604-017-2262-8]
7. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao.  (2016)  Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter.  Chemistry-An Asian Journal,  11  (14): (2041-2048).  [PMID:27252050] [10.1002/asia.201600459]
8. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire.  JOURNAL OF CHROMATOGRAPHY A,  1407  (1).  [PMID:26141275] [10.1016/j.chroma.2015.06.031]
9. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao.  (2015)  Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification.  BIOSENSORS & BIOELECTRONICS,  71  (439).  [PMID:25950941] [10.1016/j.bios.2015.04.076]
10. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.  JOURNAL OF SEPARATION SCIENCE,  38  (12): (2117-2125).  [PMID:25832420] [10.1002/jssc.201500264]
11. Zhuo Ye, Yinfeng Li, Jianguo Wen, Kunjing Li, Baoxian Ye.  (2014)  Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode.  TALANTA,  126  (38).  [PMID:24881532] [10.1016/j.talanta.2014.03.026]
12. Lihong Liu, Zilin Chen.  (2012)  Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.  ANALYTICA CHIMICA ACTA,  737  (99).  [PMID:22769040] [10.1016/j.aca.2012.05.054]
13. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu.  (2014-12-22)  Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica..  Journal of chromatography. A,  1376  (64-73).  [PMID:25528071]
14. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu.  (2015-02-03)  Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase..  Journal of separation science,  38  ((7)): (1082-1089).  [PMID:25641573]
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen.  (2015-06-04)  Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis..  Journal of separation science,  38  ((16)): (2887-2892).  [PMID:26037533]

References

1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei.  (2023)  Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids.  MICROCHIMICA ACTA,  190  (12): (1-12).  [PMID:37999777] [10.1007/s00604-023-06053-x]
2. Longlong Gao, Rui Tian, Yong Shao.  (2023)  Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site.  Chemistry-Switzerland,  (3): (1497-1507).  [PMID:] [10.3390/chemistry5030102]
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]
4. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang.  (2020)  The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance.  NEW JOURNAL OF CHEMISTRY,  44  (27): (11704-11709).  [PMID:] [10.1039/D0NJ01197E]
5. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou.  (2018)  Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study.  MOLECULES,  23  (4): (714).  [PMID:29561801] [10.3390/molecules23040714]
6. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin.  (2017)  An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS.  MICROCHIMICA ACTA,  184  (8): (2715-2721).  [PMID:] [10.1007/s00604-017-2262-8]
7. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao.  (2016)  Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter.  Chemistry-An Asian Journal,  11  (14): (2041-2048).  [PMID:27252050] [10.1002/asia.201600459]
8. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire.  JOURNAL OF CHROMATOGRAPHY A,  1407  (1).  [PMID:26141275] [10.1016/j.chroma.2015.06.031]
9. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao.  (2015)  Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification.  BIOSENSORS & BIOELECTRONICS,  71  (439).  [PMID:25950941] [10.1016/j.bios.2015.04.076]
10. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.  JOURNAL OF SEPARATION SCIENCE,  38  (12): (2117-2125).  [PMID:25832420] [10.1002/jssc.201500264]
11. Zhuo Ye, Yinfeng Li, Jianguo Wen, Kunjing Li, Baoxian Ye.  (2014)  Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode.  TALANTA,  126  (38).  [PMID:24881532] [10.1016/j.talanta.2014.03.026]
12. Lihong Liu, Zilin Chen.  (2012)  Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.  ANALYTICA CHIMICA ACTA,  737  (99).  [PMID:22769040] [10.1016/j.aca.2012.05.054]
13. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu.  (2014-12-22)  Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica..  Journal of chromatography. A,  1376  (64-73).  [PMID:25528071]
14. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu.  (2015-02-03)  Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase..  Journal of separation science,  38  ((7)): (1082-1089).  [PMID:25641573]
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen.  (2015-06-04)  Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis..  Journal of separation science,  38  ((16)): (2887-2892).  [PMID:26037533]

Solution Calculators