Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
J101538-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $29.90 | |
J101538-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $117.90 | |
J101538-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $377.90 |
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities.
Synonyms | FT-0686648 | jateorrhizine | Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy- (8CI) | Ethynyldimethylcarbinol | Trichloroethylsilicon | CHEBI:6087 | 2,2,2-Trichloro-1-ethanol | A-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium | NSC645313 |
---|---|
Specifications & Purity | analytical standard, ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb Rhizoma Coptidis. Protects neuronal-like cells against H 2 O 2 -induced toxicity. Protects against okadaic acid induced oxidative toxicity through inhibiting the Mitogen-acti |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol |
---|---|
INCHI | InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1 |
InChi Key | MXTLAHSTUOXGQF-UHFFFAOYSA-O |
Canonical SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC |
Isomeric SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC |
PubChem CID | 72323 |
Molecular Weight | 355.38 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2117162 | Certificate of Analysis | Apr 02, 2024 | J101538 |
B2303382 | Certificate of Analysis | Nov 12, 2022 | J101538 |
B2303445 | Certificate of Analysis | Nov 12, 2022 | J101538 |
E2409035 | Certificate of Analysis | Nov 12, 2022 | J101538 |
J2327246 | Certificate of Analysis | Nov 12, 2022 | J101538 |
1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei. (2023) Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids. MICROCHIMICA ACTA, 190 (12): (1-12). [PMID:37999777] [10.1007/s00604-023-06053-x] |
2. Longlong Gao, Rui Tian, Yong Shao. (2023) Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site. Chemistry-Switzerland, 5 (3): (1497-1507). [PMID:] [10.3390/chemistry5030102] |
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan. (2023) Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection. Biosensors-Basel, 13 (4): (489). [PMID:37185564] [10.3390/bios13040489] |
4. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
5. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou. (2018) Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study. MOLECULES, 23 (4): (714). [PMID:29561801] [10.3390/molecules23040714] |
6. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin. (2017) An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS. MICROCHIMICA ACTA, 184 (8): (2715-2721). [PMID:] [10.1007/s00604-017-2262-8] |
7. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao. (2016) Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter. Chemistry-An Asian Journal, 11 (14): (2041-2048). [PMID:27252050] [10.1002/asia.201600459] |
8. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen. (2015) Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire. JOURNAL OF CHROMATOGRAPHY A, 1407 (1). [PMID:26141275] [10.1016/j.chroma.2015.06.031] |
9. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao. (2015) Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification. BIOSENSORS & BIOELECTRONICS, 71 (439). [PMID:25950941] [10.1016/j.bios.2015.04.076] |
10. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen. (2015) Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma. JOURNAL OF SEPARATION SCIENCE, 38 (12): (2117-2125). [PMID:25832420] [10.1002/jssc.201500264] |
11. Zhuo Ye, Yinfeng Li, Jianguo Wen, Kunjing Li, Baoxian Ye. (2014) Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode. TALANTA, 126 (38). [PMID:24881532] [10.1016/j.talanta.2014.03.026] |
12. Lihong Liu, Zilin Chen. (2012) Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection. ANALYTICA CHIMICA ACTA, 737 (99). [PMID:22769040] [10.1016/j.aca.2012.05.054] |
13. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
14. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |
1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei. (2023) Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids. MICROCHIMICA ACTA, 190 (12): (1-12). [PMID:37999777] [10.1007/s00604-023-06053-x] |
2. Longlong Gao, Rui Tian, Yong Shao. (2023) Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site. Chemistry-Switzerland, 5 (3): (1497-1507). [PMID:] [10.3390/chemistry5030102] |
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan. (2023) Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection. Biosensors-Basel, 13 (4): (489). [PMID:37185564] [10.3390/bios13040489] |
4. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
5. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou. (2018) Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study. MOLECULES, 23 (4): (714). [PMID:29561801] [10.3390/molecules23040714] |
6. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin. (2017) An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS. MICROCHIMICA ACTA, 184 (8): (2715-2721). [PMID:] [10.1007/s00604-017-2262-8] |
7. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao. (2016) Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter. Chemistry-An Asian Journal, 11 (14): (2041-2048). [PMID:27252050] [10.1002/asia.201600459] |
8. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen. (2015) Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire. JOURNAL OF CHROMATOGRAPHY A, 1407 (1). [PMID:26141275] [10.1016/j.chroma.2015.06.031] |
9. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao. (2015) Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification. BIOSENSORS & BIOELECTRONICS, 71 (439). [PMID:25950941] [10.1016/j.bios.2015.04.076] |
10. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen. (2015) Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma. JOURNAL OF SEPARATION SCIENCE, 38 (12): (2117-2125). [PMID:25832420] [10.1002/jssc.201500264] |
11. Zhuo Ye, Yinfeng Li, Jianguo Wen, Kunjing Li, Baoxian Ye. (2014) Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode. TALANTA, 126 (38). [PMID:24881532] [10.1016/j.talanta.2014.03.026] |
12. Lihong Liu, Zilin Chen. (2012) Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection. ANALYTICA CHIMICA ACTA, 737 (99). [PMID:22769040] [10.1016/j.aca.2012.05.054] |
13. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
14. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |