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JMS-053 , CAS No.J611241, Inhibitor of protein tyrosine phosphatase 4A3

PubChem CID: 124141953

Item Number

J611241

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SKU	Size	Availability	Price	Qty
J611241-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
J611241-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$870.90

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protein tyrosine phosphatase 4A3 Inhibitor

Basic Description

Synonyms	JMS-053 \| 7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione \| 1954650-11-3 \| QBK5MBZ22Q \| CHEMBL4445621 \| SCHEMBL18323037 \| GTPL12480 \| BDBM396097 \| compound 13; JMS-631-053 \| NSC804570 \| NSC-804570 \| compound 13 [PMID: 33766767] \| PD128069 \| HY-135457 \| CS-0112952 \| 7-imino-2-ph
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein tyrosine phosphatase 4A3

Associated Targets(Human)

PTP4A2 Tchem Protein tyrosine phosphatase type IVA 2 (1 Activities)

Discover Target: PTP4A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTP4A3 Tchem Protein tyrosine phosphatase type IVA 3 (3 Activities)

Discover Target: PTP4A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTP4A1 Tchem Protein tyrosine phosphatase type IVA 1 (1 Activities)

Discover Target: PTP4A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

Discover Target: MAPK14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

Discover Target: PTPN11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRC Tchem Leukocyte common antigen (2317 Activities)

Discover Target: PTPRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTP4A3 Tchem Protein-tyrosine phosphatase 4A3 (173 Activities)

Discover Target: PTP4A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTP4A1 Tchem Protein tyrosine phosphatase type IVA 1 (47 Activities)

Discover Target: PTP4A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTP4A2 Tchem Protein tyrosine phosphatase type IVA 2 (36 Activities)

Discover Target: PTP4A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN5 Tchem Tyrosine-protein phosphatase non-receptor type 5 (536 Activities)

Discover Target: PTPN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TXN Tchem Thioredoxin (111 Activities)

Discover Target: TXN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRO Tbio Receptor-type tyrosine-protein phosphatase O (15 Activities)

Discover Target: PTPRO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)

Discover Target: Cdc25b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ptp4a3 Protein tyrosine phosphatase type IVA 3 (7 Activities)

Discover Target: Ptp4a3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-imino-2-phenylthieno[3,2-c]pyridine-4,6-dione
INCHI	InChI=1S/C13H8N2O2S/c14-10-11-8(12(16)15-13(10)17)6-9(18-11)7-4-2-1-3-5-7/h1-6,14H,(H,15,16,17)
InChi Key	CQHAROORCYWRRH-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=CC3=C(S2)C(=N)C(=O)NC3=O
Isomeric SMILES	C1=CC=C(C=C1)C2=CC3=C(S2)C(=N)C(=O)NC3=O
PubChem CID	124141953

PubChem CID

124141953

ChEMBL Ligand

CHEMBL4445621

References

1. Lin L, Lu L, Yuan C, Wang A, Zhu M, Fu X, Xing S. (2021) The dual inhibition against the activity and expression of tyrosine phosphatase PRL-3 from a rhodanine derivative.. Bioorg Med Chem Lett, 41 (3): (127981). [PMID:33766767]
2. Lazo JS, Isbell KN, Vasa SA, Llaneza DC, Rastelli EJ, Wipf P, Sharlow ER. (2023) Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase.. J Pharmacol Exp Ther, 384 (3): (429-438). [PMID:36627205]

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JMS-053 , CAS No.J611241, Inhibitor of protein tyrosine phosphatase 4A3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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