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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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J276446-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $38.90 | |
J276446-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $104.90 | |
J276446-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $194.90 | |
J276446-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $840.90 |
Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor. Antiangiogenic agent.
Synonyms | JNJ-10198409 | 627518-40-5 | PDGFR Tyrosine Kinase Inhibitor IV | N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | PDGF Receptor Tyrosine Kinase Inhibitor IV | 627512-69-0 | JNJ 10198409 | 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyra |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor (IC 50 = 4.2 nM). Antiangiogenic agent. Inhibits TGF-β1-mediated elongation and stiffening response. Selectively blocks Actn1 activation. Shows antiproliferative and antitumor effects in vivo. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
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INCHI | InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) |
InChi Key | ZDNURMVOKAERHZ-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC |
Isomeric SMILES | COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC |
PubChem CID | 9797370 |
Molecular Weight | 325.34 |
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Solubility | Soluble in ethanol to 25 mM and in DMSO to 75 mM |
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