Grouped product items

SKU

Size

Availability

Price

Qty

S126246-5mg

5mg

In stock

$78.90

S126246-10mg

10mg

In stock

$127.90

S126246-25mg

25mg

In stock

$288.90

S126246-50mg

50mg

In stock

$444.90

S126246-100mg

100mg

In stock

$741.90

Basic Description

Synonyms	CCG-264846 \| AS-56263 \| NCGC00263171-01 \| 2-(Furan-2-yl)thiazolidine-4-carboxylicacid \| JNJ-26854165 (Serdemetan) \| CS-0166 \| FT-0689750 \| N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine \| PBANXRNIXGEHPZ-UHFFFAOYSA-N \| JNJ 26854165 \| BCP0
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	JNJ 26854165 is a tryptamine derivative which activates p53 and acts as an HDM2 ubiquitin ligase(MDM2) inhibitor. JNJ 26854165 inhibits cell growth and induces apoptosis in leukemia cell lines. JNJ 26854165 is an MDM2 inhibitor which can inhibit the inter
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. A p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor

Associated Targets(Human)

5637 (630 Activities)

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A 172 (535 Activities)

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A204 (242 Activities)

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A2058 (690 Activities)

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A-375 (9258 Activities)

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A-427 (643 Activities)

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A498 (42825 Activities)

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A673 (619 Activities)

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ACHN (49357 Activities)

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AGS (1999 Activities)

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BT-20 (503 Activities)

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BT-474 (2113 Activities)

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BXPC-3 (2997 Activities)

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CAKI-1 (44928 Activities)

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Calu-3 (339 Activities)

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Calu-6 (398 Activities)

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CAPAN-1 (772 Activities)

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CFPAC-1 (421 Activities)

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COR-L23 (253 Activities)

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Daoy (570 Activities)

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DMS-273 (14108 Activities)

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DU-145 (51482 Activities)

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EVSA-T (142 Activities)

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G-361 (890 Activities)

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G-401 (156 Activities)

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HT-1080 (3966 Activities)

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HT-29 (80576 Activities)

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HuCCT-1 (128 Activities)

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Huh-7 (12904 Activities)

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HuTu80 (255 Activities)

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J82 (505 Activities)

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JAR (316 Activities)

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KM12 (47707 Activities)

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LoVo (4724 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MDA-MB-361 (612 Activities)

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MDA-MB-453 (1139 Activities)

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MES-SA (905 Activities)

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MG-63 (795 Activities)

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NCI-H1975 (4994 Activities)

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MKN-1 (175 Activities)

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MKN-28 (466 Activities)

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MKN-45 (2102 Activities)

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MKN-7 (272 Activities)

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NCI-H358 (882 Activities)

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NCI-N87 (850 Activities)

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NTERA-2-cl-D1 (234 Activities)

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NUGC-3 (976 Activities)

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OVCAR-3 (48710 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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H4 (48 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
INCHI	InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChi Key	CEGSUKYESLWKJP-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
PubChem CID	11609586
Molecular Weight	328.42

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
I2205362	Certificate of Analysis	Jun 13, 2022	S126246
I2205363	Certificate of Analysis	Jun 13, 2022	S126246
I2205396	Certificate of Analysis	Jun 13, 2022	S126246
I2205397	Certificate of Analysis	Jun 13, 2022	S126246
I2205398	Certificate of Analysis	Jun 13, 2022	S126246

Chemical and Physical Properties

Solubility	DMSO ≥64mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL；insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao. (2023) MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy. JOURNAL OF HAZARDOUS MATERIALS, 457 (131750). [PMID:37315416] [10.1016/j.jhazmat.2023.131750]

References

1. Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao. (2023) MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy. JOURNAL OF HAZARDOUS MATERIALS, 457 (131750). [PMID:37315416] [10.1016/j.jhazmat.2023.131750]

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JNJ-26854165 (Serdemetan) - ≥98%, high purity , CAS No.881202-45-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator