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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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J413415-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
J413415-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $629.90 | |
J413415-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $899.90 | |
J413415-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,199.90 |
Synonyms | JNJ-40411813|1127498-03-6|ADX-71149|JNJ40411813|JNJ 40411813|2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-|1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one|CHEMBL3337527|1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone|1- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | JNJ-40411813 (ADX-71149) is a positive allosteric modulator (PAM) of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR, POSITIVE ALLOSTERIC MODULATOR |
Mechanism of action | Metabotropic glutamate receptor 2 positive allosteric modulator |
Product Description | Information JNJ-40411813 (ADX-71149) is a positive allosteric modulator (PAM) of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. |
ALogP | 4.6 |
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IUPAC Name | 1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one |
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INCHI | InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3 |
InChi Key | HYOGJHCDLQSAHX-UHFFFAOYSA-N |
Canonical SMILES | CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)C3=CC=CC=C3 |
Isomeric SMILES | CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)C3=CC=CC=C3 |
PubChem CID | 25195461 |
Molecular Weight | 344.88 |
PubChem CID | 25195461 |
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CAS Registry No. | 1127498-03-6 |
RCSB PDB Ligand | HZR |
GPCRdb Ligand | JNJ-40411813 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2419311 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419312 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419313 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419314 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419315 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419316 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419317 | Certificate of Analysis | Jan 27, 2024 | J413415 |
C2419318 | Certificate of Analysis | Jan 27, 2024 | J413415 |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
1. Cid JM, Tresadern G, Duvey G, Lütjens R, Finn T, Rocher JP, Poli S, Vega JA, de Lucas AI, Matesanz E et al.. (2014) Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.. J Med Chem, 57 (15): (6495-512). [PMID:25032784] |
2. Lavreysen H, Ahnaou A, Drinkenburg W, Langlois X, Mackie C, Pype S, Lütjens R, Le Poul E, Trabanco AA, Nuñez JM. (2015) Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor.. Pharmacol Res Perspect, 3 (1): (e00096). [PMID:25692015] |
3. Lavreysen H, Langlois X, Donck LV, Nuñez JM, Pype S, Lütjens R, Megens A. (2015) Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813.. Pharmacol Res Perspect, 3 (2): (e00097). [PMID:25692027] |
4. Salih H, Anghelescu I, Kezic I, Sinha V, Hoeben E, Van Nueten L, De Smedt H, De Boer P. (2015) Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies.. J Psychopharmacol (Oxford), 29 (4): (414-25). [PMID:25735992] |