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G protein-coupled receptors (GPCRs)
Metabotropic glutamate receptors
JNJ-46281222 , CAS No.J611269, Allosteric modulator of mGlu 2 receptor

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JNJ-46281222 , CAS No.J611269, Allosteric modulator of mGlu 2 receptor

Moligand™

PubChem CID: 49822115

Item Number

J611269

Grouped product items
SKU	Size	Availability	Price	Qty
J611269-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$310.90
J611269-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,070.90

View related series

mGlu2 receptor Allosteric modulator

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 2 receptor

Associated Targets(Human)

GRM2 Tchem Metabotropic glutamate receptor 2 (6 Activities)

Discover Target: GRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)

Discover Target: Grm2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-(cyclopropylmethyl)-7-[(4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
INCHI	InChI=1S/C23H25F3N4/c24-23(25,26)21-19(10-13-30-20(14-16-6-7-16)27-28-22(21)30)15-29-11-8-18(9-12-29)17-4-2-1-3-5-17/h1-5,10,13,16,18H,6-9,11-12,14-15H2
InChi Key	LYDKDODJIBQNLK-UHFFFAOYSA-N
Canonical SMILES	FC(c1c(ccn2c1nnc2CC1CC1)CN1CCC(CC1)c1ccccc1)(F)F
Isomeric SMILES	C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)CN4CCC(CC4)C5=CC=CC=C5
PubChem CID	49822115

Database links

PubChem CID	49822115
GPCRdb Ligand	JNJ-46281222

Certificates

Certificate of Analysis(COA)

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References

1. Doornbos ML, Pérez-Benito L, Tresadern G, Mulder-Krieger T, Biesmans I, Trabanco AA, Cid JM, Lavreysen H, IJzerman AP, Heitman LH. (2016) Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.. Br J Pharmacol, 173 (3): (588-600). [PMID:26589404] [10.1021/op500134e]

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