Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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J463189-100mg | 100mg | In stock | $199.90 | |
J463189-250mg | 250mg | In stock | $259.90 | |
J463189-1g | 1g | In stock | $439.90 |
Synonyms | josamycin | Leucomycin A3 | Turimycin A5 | Kitasamycin A3 | Josamycine | 16846-24-5 | Antibiotic yl-704 A3 | Josamicina | Josamycinum | Josamycine [INN-French] | Josamycinum [INN-Latin] | iosalide | josamina | Josamicina [INN-Spanish] | EN-141 | Yl-704 A3 | Jomybel | Josacine | Leucomycin V |
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Specifications & Purity | ≥900U/mg |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Product Description | Description Chemical structure: macrolideJosamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit. |
ALogP | 2.9 |
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IUPAC Name | [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate |
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INCHI | InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1 |
InChi Key | XJSFLOJWULLJQS-NGVXBBESSA-N |
Canonical SMILES | CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)OC(=O)C)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O |
Isomeric SMILES | C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O |
PubChem CID | 5282165 |
Molecular Weight | 827.99 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2416467 | Certificate of Analysis | Jul 20, 2024 | J463189 |
H2416468 | Certificate of Analysis | Jul 20, 2024 | J463189 |
C2408009 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318114 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318115 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318116 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318117 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318118 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318119 | Certificate of Analysis | Jul 26, 2023 | J463189 |
Sensitivity | Moisture sensitive;Light sensitive |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Starting at $241.90
Starting at $927.90
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2. Martin Lovmar,Tanel Tenson,Måns Ehrenberg. (2004-09-24) Kinetics of macrolide action: the josamycin and erythromycin cases.. The Journal of biological chemistry, 279 ((51)): (53506-53515). [PMID:15385552] |
3. Christopher A Elkins,Lisa B Mullis. (2007-01-11) Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.. Antimicrobial agents and chemotherapy, 51 ((3)): (923-929). [PMID:17210767] |
4. Laura Calatayud,C Ardanuy,E Cercenado,A Fenoll,E Bouza,R Pallares,R Martín,J Liñares. (2007-07-04) Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain.. Antimicrobial agents and chemotherapy, 51 ((9)): (3240-3246). [PMID:17606677] |
5. Rachel Binet,Anthony T Maurelli. (2007-10-03) Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2.. Antimicrobial agents and chemotherapy, 51 ((12)): (4267-4275). [PMID:17908942] |
6. M Weidlich,C Klammt,F Bernhard,M Karas,T Stein. (2007-11-22) Differential activity profiles of translation inhibitors in whole-cell and cell-free approaches.. Letters in applied microbiology, 46 ((2)): (155-159). [PMID:18028330] |
7. P Charles,P Stumpf,P Buffet,A Hot,M Lecuit,B Dupont,O Lortholary,P-H Consigny. (2008-01-15) Two unusual glandular presentations of tick-borne tularemia.. Medecine et maladies infectieuses, 38 ((3)): (159-161). [PMID:18191519] |
8. Lisa K Smith,Alexander S Mankin. (2008-02-27) Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors.. Antimicrobial agents and chemotherapy, 52 ((5)): (1703-1712). [PMID:18299405] |
9. Adeline Achard,Véronique Guérin-Faublée,Vianney Pichereau,Corinne Villers,Roland Leclercq. (2008-06-04) Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene.. Antimicrobial agents and chemotherapy, 52 ((8)): (2767-2770). [PMID:18519724] |
10. Deli Xin,Zuhuang Mi,Xu Han,Ling Qin,Jing Li,Tianli Wei,Xiaogeng Chen,Shaojie Ma,Ancun Hou,Gui Li,Dawei Shi. (2009-03-11) Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.. Antimicrobial agents and chemotherapy, 53 ((5)): (2158-2159). [PMID:19273685] |
11. Martin Lovmar,Vladimir Vimberg,Eliisa Lukk,Karin Nilsson,Tanel Tenson,Måns Ehrenberg. (2009-05-26) Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin.. Biochimie, 91 ((8)): (989-995). [PMID:19463886] |
12. H See,J Lachenaud,C Alberti,P Mariani-Kurkdjian,Y Aujard,O Baud. (2010-01-09) Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine.. Acta paediatrica (Oslo, Norway : 1992), 99 ((4)): (625-626). [PMID:20055775] |
13. Yun Zhou,Xue-Lan Xu,Chun-Ping Wang,Ming Zhou,Xiu-Hua Zeng. (2011-10-08) [Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility].. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 25 ((3)): (201-204). [PMID:21977592] |
14. Giuseppe Alessio Messano,Stefano Petti. (2012-04-18) [Antibiotic resistance as a public health problem: the case of genital mycoplasmoses].. Igiene e sanita pubblica, 67 ((6)): (697-706). [PMID:22508643] |
15. I V Semenova,O A Gizinger,O R Ziganshina,Iu A Semenov,I I Dolgushin,O I Letiaeva. (2012-08-23) [The influence of ultrasonic radiation on the factors of antimicrobial resistance in the women of reproductive age presenting with mycoplasma infection of the urogenital tract].. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, ((2)(2)): (23-27). [PMID:22908470] |
16. Lihong Gao,Yali Shi,Wenhui Li,Jiemin Liu,Yaqi Cai. (2015-03-26) Occurrence and distribution of antibiotics in urban soil in Beijing and Shanghai, China.. Environmental science and pollution research international, 22 ((15)): (11360-11371). [PMID:25804657] |
17. Maki Kanda,Takayuki Nakajima,Hiroshi Hayashi,Tsuneo Hashimoto,Setsuko Kanai,Chieko Nagano,Yoko Matsushima,Yukinari Tateishi,Soichi Yoshikawa,Yumi Tsuruoka,Takeo Sasamoto,Ichiro Takano. (2015-04-11) Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.. Journal of AOAC International, 98 ((1)): (230-247). [PMID:25857903] |
18. Qiang Xue,Yanjie Qi,Fei Liu. (2015-06-25) Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.. Environmental science and pollution research international, 22 ((21)): (16857-16867). [PMID:26104902] |
19. I Querol Nasarre,M T Cisneros Lanuza,E Urbiola Marcilla. (1993-09-01) [A tick bite and lymphadenosis benigna cutis in childhood. Their treatment with josamycin].. Anales espanoles de pediatria, 39 ((3)): (251-254). [PMID:8250442] |
20. Biyang Deng,Yanhui Kang,Xianfeng Li,Qiumei Xu. (2007-10-12) Determination of josamycin in rat plasma by capillary electrophoresis coupled with post-column electrochemiluminescence detection.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859 ((1)): (125-130). [PMID:17928277] |
21. Xue-Mei Ou,Yu-Ling Feng,Fu-Qiang Wen,Ke Wang,Jie Yang,Zhi-Pin Deng,Dai-Shun Liu,Yan-Ping Li. (2008-01-17) Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-kappaB.. Respirology (Carlton, Vic.), 13 ((1)): (63-72). [PMID:18197913] |
22. Yu-Hong Min,Ae-Ran Kwon,Jong-Min Yoon,Eun-Jeong Yoon,Mi-Ja Shim,Eung-Chil Choi. (2008-04-15) Molecular analysis of constitutive mutations in ermB and ermA selected in vitro from inducibly MLSB-resistant enterococci.. Archives of pharmacal research, 31 ((3)): (377-380). [PMID:18409053] |
23. A A Khrianin,O V Reshetnikov. (2008-11-07) [Is it safe to use josamycin in the obstetrics practice in Russia?].. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 52 ((7-8)): (32-36). [PMID:18986022] |
24. Piotr Przybylski,Krystian Pyta,Bogumil Brzezinski. (2009-07-02) Fragmentation pathways of new aza derivatives of 16-membered macrolide antibiotic--analog of Josamycin investigated by ESI and FAB mass spectrometric methods.. Journal of mass spectrometry : JMS, 44 ((9)): (1395-1401). [PMID:19569070] |
25. Piotr Przybylski,Krystian Pyta,Joanna Stefańska,Bogumil Brzezinski,Franz Bartl. (2010-02-27) Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin.. Magnetic resonance in chemistry : MRC, 48 ((4)): (286-296). [PMID:20186698] |
26. Takeshi Shimizu,Shino Shimizu. (2012-05-12) Azithromycin inhibits mucus hypersecretion from airway epithelial cells.. Mediators of inflammation, 2012 (265714-265714). [PMID:22577246] |
27. Wenhui Li,Lihong Gao,Yali Shi,Jiemin Liu,Yaqi Cai. (2015-08-08) Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China.. Environmental science. Processes & impacts, 17 ((9)): (1611-1619). [PMID:26245300] |