Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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J463189-100mg | 100mg | In stock | $199.90 | |
J463189-250mg | 250mg | In stock | $259.90 | |
J463189-1g | 1g | In stock | $439.90 |
Synonyms | HV13HFS217 | iosalide | (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy |
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Specifications & Purity | ≥900U/mg |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Product Description | Description Chemical structure: macrolideJosamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit. |
ALogP | 2.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate |
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INCHI | InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1 |
InChi Key | XJSFLOJWULLJQS-NGVXBBESSA-N |
Canonical SMILES | CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)OC(=O)C)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O |
Isomeric SMILES | C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O |
PubChem CID | 5282165 |
Molecular Weight | 827.99 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2416467 | Certificate of Analysis | Jul 20, 2024 | J463189 |
H2416468 | Certificate of Analysis | Jul 20, 2024 | J463189 |
C2408009 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318114 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318115 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318116 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318117 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318118 | Certificate of Analysis | Jul 26, 2023 | J463189 |
H2318119 | Certificate of Analysis | Jul 26, 2023 | J463189 |
Sensitivity | Moisture sensitive;Light sensitive |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Starting at $241.90
Starting at $927.90
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2. Martin Lovmar,Tanel Tenson,Måns Ehrenberg. (2004-09-24) Kinetics of macrolide action: the josamycin and erythromycin cases.. The Journal of biological chemistry, 279 ((51)): (53506-53515). [PMID:15385552] |
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9. Adeline Achard,Véronique Guérin-Faublée,Vianney Pichereau,Corinne Villers,Roland Leclercq. (2008-06-04) Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene.. Antimicrobial agents and chemotherapy, 52 ((8)): (2767-2770). [PMID:18519724] |
10. Deli Xin,Zuhuang Mi,Xu Han,Ling Qin,Jing Li,Tianli Wei,Xiaogeng Chen,Shaojie Ma,Ancun Hou,Gui Li,Dawei Shi. (2009-03-11) Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.. Antimicrobial agents and chemotherapy, 53 ((5)): (2158-2159). [PMID:19273685] |
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12. H See,J Lachenaud,C Alberti,P Mariani-Kurkdjian,Y Aujard,O Baud. (2010-01-09) Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine.. Acta paediatrica (Oslo, Norway : 1992), 99 ((4)): (625-626). [PMID:20055775] |
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17. Maki Kanda,Takayuki Nakajima,Hiroshi Hayashi,Tsuneo Hashimoto,Setsuko Kanai,Chieko Nagano,Yoko Matsushima,Yukinari Tateishi,Soichi Yoshikawa,Yumi Tsuruoka,Takeo Sasamoto,Ichiro Takano. (2015-04-11) Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.. Journal of AOAC International, 98 ((1)): (230-247). [PMID:25857903] |
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20. I Querol Nasarre,M T Cisneros Lanuza,E Urbiola Marcilla. (1993-09-01) [A tick bite and lymphadenosis benigna cutis in childhood. Their treatment with josamycin].. Anales espanoles de pediatria, 39 ((3)): (251-254). [PMID:8250442] |
21. Biyang Deng,Yanhui Kang,Xianfeng Li,Qiumei Xu. (2007-10-12) Determination of josamycin in rat plasma by capillary electrophoresis coupled with post-column electrochemiluminescence detection.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859 ((1)): (125-130). [PMID:17928277] |
22. Xue-Mei Ou,Yu-Ling Feng,Fu-Qiang Wen,Ke Wang,Jie Yang,Zhi-Pin Deng,Dai-Shun Liu,Yan-Ping Li. (2008-01-17) Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-kappaB.. Respirology (Carlton, Vic.), 13 ((1)): (63-72). [PMID:18197913] |
23. Yu-Hong Min,Ae-Ran Kwon,Jong-Min Yoon,Eun-Jeong Yoon,Mi-Ja Shim,Eung-Chil Choi. (2008-04-15) Molecular analysis of constitutive mutations in ermB and ermA selected in vitro from inducibly MLSB-resistant enterococci.. Archives of pharmacal research, 31 ((3)): (377-380). [PMID:18409053] |
24. A A Khrianin,O V Reshetnikov. (2008-11-07) [Is it safe to use josamycin in the obstetrics practice in Russia?].. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 52 ((7-8)): (32-36). [PMID:18986022] |
25. Piotr Przybylski,Krystian Pyta,Bogumil Brzezinski. (2009-07-02) Fragmentation pathways of new aza derivatives of 16-membered macrolide antibiotic--analog of Josamycin investigated by ESI and FAB mass spectrometric methods.. Journal of mass spectrometry : JMS, 44 ((9)): (1395-1401). [PMID:19569070] |
26. Piotr Przybylski,Krystian Pyta,Joanna Stefańska,Bogumil Brzezinski,Franz Bartl. (2010-02-27) Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin.. Magnetic resonance in chemistry : MRC, 48 ((4)): (286-296). [PMID:20186698] |
27. Takeshi Shimizu,Shino Shimizu. (2012-05-12) Azithromycin inhibits mucus hypersecretion from airway epithelial cells.. Mediators of inflammation, 2012 (265714-265714). [PMID:22577246] |