JQ1 is a member of the triazolo-diazepine compound family, which functions as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.
Product Application：
(+)-JQ1 has been used in flow cytometry assay, cell viability assay and quantitative PCR assay in order to investigate on the reversal of HIV-1 latency.
Associated Targets
BRD4Tchem Bromodomain-containing protein 4 115 Activities
1.Kim E et al.. (2018) Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma.. Sci Rep, 8 (10590). [PMID:30002430]
2.Yamamoto T et al.. (2020) BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene.. Br J Cancer, [PMID:32499570]
3.Matsuda Y et al.. (2022) Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma.. Cancer Sci, 113 (4):(1208-1219). [PMID:35133054]
4.Albarnaz JD et al.. (2022) Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses.. Nat Microbiol, 7 (154-168). [PMID:34949827]
5.Kramer M et al.. (2016) Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.. J Neurosci, 36 (40):(10425-10439). [PMID:27707976]
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