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JTE 013 - ≥98%(HPLC), high purity , CAS No.383150-41-2, Antagonist of P2RY10;Antagonist of S1P 2 receptor
Basic Description Synonyms JTE-013|383150-41-2|Jte 013|1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea|CHEMBL1368758|N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide|N-( Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of P2RY10;Antagonist of S1P 2 receptor Product Description JTE-013 has been used in in vitro blood−brain barrier (BBB) and blood−tumor barrier (BTB) assays.
Names and Identifiers IUPAC Name 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea INCHI InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27) InChi Key RNSLRQNDXRSASX-UHFFFAOYSA-N Canonical SMILES CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C Isomeric SMILES CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C PubChem CID 10223146 Molecular Weight 408.29
Chemical and Physical Properties Solubility Soluble in DMSO, the highest concentration (mg / ml): 100, the highest concentration (mm): 244.92 (need ultrasonic); Soluble in ethanol, the highest concentration (mg / ml): 40.83, the highest concentration (mm): 100
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
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