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Enzyme inhibitors and enzyme substrates
JTP 103237 - ≥98%(HPLC), high purity , CAS No.1883864-16-1

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JTP 103237 - ≥98%(HPLC), high purity , CAS No.1883864-16-1

≥98%(HPLC)

CAS#: 1883864-16-1
Formula: C₂₄H₂₉F₃N₆O
Molecular Weight: 474.52
PubChem CID: 91884614

Item Number

J287919

Grouped product items
SKU	Size	Availability	Price	Qty
J287919-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$189.90
J287919-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$797.90

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor

Basic Description

Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50= 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatt
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

MGAT2 Tchem Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (1 Activities)

Discover Target: MGAT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DGAT2 Tchem Diacylglycerol O-acyltransferase 2 (347 Activities)

Discover Target: DGAT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	7-(4,6-ditert-butylpyrimidin-2-yl)-3-[4-(trifluoromethoxy)phenyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine
INCHI	InChI=1S/C24H29F3N6O/c1-22(2,3)17-13-18(23(4,5)6)29-21(28-17)32-11-12-33-19(14-32)30-31-20(33)15-7-9-16(10-8-15)34-24(25,26)27/h7-10,13H,11-12,14H2,1-6H3
InChi Key	KELNXHBJTXCXSN-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=NC(=N1)N2CCN3C(=NN=C3C4=CC=C(C=C4)OC(F)(F)F)C2)C(C)(C)C
Isomeric SMILES	CC(C)(C)C1=CC(=NC(=N1)N2CCN3C(=NN=C3C4=CC=C(C=C4)OC(F)(F)F)C2)C(C)(C)C
PubChem CID	91884614
Molecular Weight	474.52

Certificates

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Chemical and Physical Properties

Solubility	Solvent:ethanol, Max Conc. mg/mL: 47.45, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 9.49, Max Conc. mM: 20

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