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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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J288239-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $85.90 | |
J288239-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $114.90 | |
J288239-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $319.90 | |
J288239-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $373.90 | |
J288239-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $855.90 |
Wnt pathway inhibitor
Synonyms | JW74;JW-74; 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
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Specifications & Purity | ≥99%(HPLC) |
Biochemical and Physiological Mechanisms | Inhibitor of canonical Wnt signaling (IC50= 790 nM). Targets theβ-catenin destruction complex (GSK-3 beta /AXIN/APC). Increases AXIN2 and decreases activeβ-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1and inhibits prolifer |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling with an IC50 of 420 nM. Application:
JW74 has also been used to test its efficacy in concurrent radiation and cisplatin (CDDP)-mediated cytotoxicity using HeLa and cervical carcinoma SiHa cell lines. It has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
JW74 has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
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IUPAC Name | 5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole |
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INCHI | InChI=1S/C24H20N6O2S/c1-16-3-5-17(6-4-16)22-26-21(32-29-22)15-33-24-28-27-23(18-11-13-25-14-12-18)30(24)19-7-9-20(31-2)10-8-19/h3-14H,15H2,1-2H3 |
InChi Key | KRIKILRRJCIWNB-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC=C(C=C1)C2=NOC(=N2)CSC3=NN=C(N3C4=CC=C(C=C4)OC)C5=CC=NC=C5 |
Isomeric SMILES | CC1=CC=C(C=C1)C2=NOC(=N2)CSC3=NN=C(N3C4=CC=C(C=C4)OC)C5=CC=NC=C5 |
WGK Germany | 3 |
PubChem CID | 16013152 |
Molecular Weight | 456.52 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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A2420238 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420239 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420240 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420241 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420242 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420247 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420248 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420249 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420250 | Certificate of Analysis | Dec 20, 2023 | J288239 |
A2420251 | Certificate of Analysis | Dec 20, 2023 | J288239 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 45.65, Max Conc. mM: 100 |
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WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |