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JZL184 - 96%, high purity , CAS No.1101854-58-3
Basic Description Synonyms JZL184 | 1101854-58-3 | JZL 184 | JZL-184 | 4-nitrophenyl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate | 7MZ1I2J68A | CHEMBL576786 | 4-Nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate | 1-Piperidinecarboxylic ac Specifications & Purity Moligand™, ≥96% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description product description：
JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate INCHI InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2 InChi Key SEGYOKHGGFKMCX-UHFFFAOYSA-N Canonical SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-] Isomeric SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-] PubChem CID 25021165 Molecular Weight 520.5
Chemical and Physical Properties Solubility insoluble in H2O; insoluble in EtOH; ≥20.35 mg/mL in DMSO
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F22041034