JZL195 - 98% , high purity , CAS No.1210004-12-8, Inhibitor of acyloxyacyl hydrolase;Inhibitor of Fatty acid amide hydrolase;Inhibitor of Monoacylglycerol lipase
JZL195 - 98% , high purity , CAS No.1210004-12-8, Inhibitor of acyloxyacyl hydrolase;Inhibitor of Fatty acid amide hydrolase;Inhibitor of Monoacylglycerol lipase
JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein c
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of acyloxyacyl hydrolase;Inhibitor of Fatty acid amide hydrolase;Inhibitor of Monoacylglycerol lipase
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
JZL195 has been used:
as a selective inhibitor of endocannabinoid (eCB) clearance enzymes to induce in vivo long-term depression at CA3-CA1 synapses and at prelimbic (PrL)-nucleus accumbens (NAc)synapses, to study the neuroprotective action of eCB
to inhibit the action of hydrolytic enzymes that limit eCB activity, to study the effect of 2-linoleoylglycerol (2-LG) on the human CB1 receptor activity
as a dual fatty acid amide hydrolase (FAAH)/monoacylglycerol lipase (MAGL) inhibitor to study its dose-related antipruritic effect on the serotonin (5-HT)-induced scratching model
1.Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL et al.. (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.. Proc Natl Acad Sci USA, 106 (48):(20270-5). [PMID:19918051][10.1021/op500134e]
2.Anderson WB, Gould MJ, Torres RD, Mitchell VA, Vaughan CW. (2014) Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.. Neuropharmacology, 81 (13):(224-30). [PMID:24384256][10.1021/op500134e]
3.Sakin YS, Dogrul A, Ilkaya F, Seyrek M, Ulas UH, Gulsen M, Bagci S. (2015) The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents.. Neurogastroenterol Motil, 27 (7):(936-44). [PMID:25869205][10.1021/op500134e]
4.Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE et al.. (2015) Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.. J Pharmacol Exp Ther, 354 (2):(111-20). [PMID:25998048][10.1021/op500134e]
5.Adamson Barnes NS, Mitchell VA, Kazantzis NP, Vaughan CW. (2016) Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.. Br J Pharmacol, 173 (1):(77-87). [PMID:26398331][10.1021/op500134e]
6.Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.. Nat Chem Biol, 10 (8):(656-63). [PMID:24997602][10.1021/op500134e]
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A2205241