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JZP 361 - 98%, high purity , CAS No.1680193-80-9
Potent and selective reversible MAGL inhibitor
Basic Description Synonyms [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmethanone | [4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-(1,2,4-triazol-1-yl)methanon Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent and selective reversible MAGL inhibitor (IC50= 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50values are 1.79 and 7.24μM, respectively). Displays affinity for H1receptors (pA2= 6.81). Exhibits Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone INCHI InChI=1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2 InChi Key GAVZCGTYRWKKDV-UHFFFAOYSA-N Canonical SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)N4C=NC=N4)C5=C1C=CC=N5 Isomeric SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)N4C=NC=N4)C5=C1C=CC=N5 PubChem CID 102596130 Molecular Weight 405.88
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 40.59, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 8.12, Max Conc. mM: 20
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