K67 - 98%, high purity , CAS No.2046250-48-8

Item Number

K648261

Grouped product items
SKU	Size	Availability	Price
K648261-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$120.90
K648261-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$220.90
K648261-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
K648261-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$890.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	K67 specifically inhibits the interaction between Keap1 and S 349 -phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S 351 -phosphorylated p62
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	K67 specifically inhibits the interaction between Keap1 and S 349 -phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S 351 -phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1. Form:Solid

Associated Targets(Human)

KEAP1 Tclin Kelch-like ECH-associated protein 1 (1736 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NFE2L2 Tchem Keap1/Nrf2 (1722 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KEAP1 Tclin Keap1-p62 (11 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-ethoxy-N-[4-[(4-ethoxyphenyl)sulfonylamino]-3-(2-oxopropyl)naphthalen-1-yl]benzenesulfonamide
INCHI	InChI=1S/C29H30N2O7S2/c1-4-37-22-10-14-24(15-11-22)39(33,34)30-28-19-21(18-20(3)32)29(27-9-7-6-8-26(27)28)31-40(35,36)25-16-12-23(13-17-25)38-5-2/h6-17,19,30-31H,4-5,18H2,1-3H3
InChi Key	VUIVGOOWLHGDPZ-UHFFFAOYSA-N
Canonical SMILES	CCOC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)NS(=O)(=O)C4=CC=C(C=C4)OCC)CC(=O)C
Isomeric SMILES	CCOC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)NS(=O)(=O)C4=CC=C(C=C4)OCC)CC(=O)C
PubChem CID	119057445
Molecular Weight	582.69

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Basic Description