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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K276587-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $73.90 |
Prototypic kainate receptor agonist. 1 ml water soluble pack.
Synonyms | Acide kainique | Digenic acid | Helminal | L-alpha-Kainic acid | Digenin | kainic acid | Kainate | Acido kainico | Digensaeure |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Soluble in 1 ml water to give specified mM/ml concentration. Find out more. |
Storage Temp | Desiccated,Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GluK1;Agonist of GluK2;Agonist of GluK3;Agonist of GluK4;Agonist of GluK5 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid |
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INCHI | InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 |
InChi Key | VLSMHEGGTFMBBZ-OOZYFLPDSA-N |
Canonical SMILES | CC(=C)C1CNC(C1CC(=O)O)C(=O)O |
Isomeric SMILES | CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O |
PubChem CID | 10255 |
Molecular Weight | 213.233 |
PubChem CID | 73755076 |
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Wikipedia | Kainic_acid |
CAS Registry No. | 487-79-6 |
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Solubility | Soluble in 1ml of water to give specified mM/ml concentration |
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Melt Point(°C) | 251°C |
Signal | Warning |
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Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell. |
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1. Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E. (2010) Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.. Mol Pharmacol, 78 (6): (1036-45). [PMID:20837679] [10.1021/op500134e] |
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24. Irvine MW et al.. (2012) Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.. J Med Chem, 55 (327-41). [PMID:22111545] |
25. Menteyne A et al.. (2009) Predominant functional expression of Kv1.3 by activated microglia of the hippocampus after Status epilepticus.. PLoS One, 4 (8): (e6770). [PMID:19707551] |
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34. Xiuping He, Jianlei Chen, Jiangtao Wang, Liju Tan. (2017) Multipoint recognition of domoic acid from seawater by dummy template molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1500 (61). [PMID:28442131] [10.1016/j.chroma.2017.04.023] |