Kanamycin sulfate - USP, high purity , CAS No.25389-94-0

27 Citations
Item Number
K103024
Grouped product items
SKUSizeAvailabilityPrice Qty
K103024-1g
1g
In stock
$49.90
K103024-5g
5g
In stock
$152.90
K103024-25g
25g
In stock
$516.90
K103024-100g
100g
In stock
$1,860.90
K103024-500g
500g
In stock
$8,372.90

Aminoglycoside antibiotic agent.

View related series
Aminoglycoside Antibiotics

Basic Description

SynonymsCantrex | KANAMYCIN MONO SULFATE | Kannasyn | J80EX28SMQ | KANAMYCIN SULFATE [GREEN BOOK] | KANAMYCIN A SULFATE [MI] | Kanamytrex | Kanatrol | s2315 | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydro
Specifications & PurityPharmPure™, USP
Biochemical and Physiological MechanismsMode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.Aminoglycoside antibiotic agent effective against Gram-negative and Gram-positive b
Storage TempStore at 2-8°C
Shipped InWet ice
GradePharmPure™, USP
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Used in biotechnology applications to inhibit protein synthesis. Used as a selection agent for cells transformed with kanamycin B (neoR, kanR) resistance gene.

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella (646 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella enteritidis (727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Serratia marcescens (3237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488189781
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189781
IUPAC Name (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
INCHI InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChi Key OOYGSFOGFJDDHP-KMCOLRRFSA-N
Canonical SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
RTECS NZ3225030
Alternate CAS 70560-51-9
PubChem CID 441374
UN Number 2811
Packing Group III
Molecular Weight 582.58
Beilstein 18(4)7631
Reaxy-Rn 3874279

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

32 results found

Lot NumberCertificate TypeDateItem
I2207828Certificate of AnalysisJun 18, 2024 K103024
I2207826Certificate of AnalysisJun 18, 2024 K103024
F2420162Certificate of AnalysisJun 07, 2024 K103024
F2420161Certificate of AnalysisJun 07, 2024 K103024
F2420160Certificate of AnalysisJun 07, 2024 K103024
F2420159Certificate of AnalysisJun 07, 2024 K103024
K2328376Certificate of AnalysisNov 21, 2023 K103024
J2309405Certificate of AnalysisSep 13, 2023 K103024
J2309256Certificate of AnalysisSep 13, 2023 K103024
J2309236Certificate of AnalysisSep 13, 2023 K103024
F2315286Certificate of AnalysisMay 19, 2023 K103024
F2315273Certificate of AnalysisMay 19, 2023 K103024
F2315268Certificate of AnalysisMay 19, 2023 K103024
F2315245Certificate of AnalysisMay 19, 2023 K103024
F2315224Certificate of AnalysisMay 19, 2023 K103024
F2315256Certificate of AnalysisMay 19, 2023 K103024
F2315223Certificate of AnalysisMay 19, 2023 K103024
F2315222Certificate of AnalysisMay 19, 2023 K103024
F2315217Certificate of AnalysisMay 19, 2023 K103024
F2315190Certificate of AnalysisMay 19, 2023 K103024
H2125292Certificate of AnalysisMay 15, 2023 K103024
D2117212Certificate of AnalysisJan 15, 2023 K103024
D2117211Certificate of AnalysisJan 15, 2023 K103024
G2214017Certificate of AnalysisJul 18, 2022 K103024
E2319212Certificate of AnalysisJun 21, 2022 K103024
I2207827Certificate of AnalysisJun 21, 2022 K103024
I2207829Certificate of AnalysisJun 21, 2022 K103024
C2314327Certificate of AnalysisJun 21, 2022 K103024
E2230021Certificate of AnalysisJun 07, 2022 K103024
B2211056Certificate of AnalysisFeb 16, 2022 K103024
D2220106Certificate of AnalysisFeb 15, 2022 K103024
H2125306Certificate of AnalysisJun 15, 2021 K103024

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Chemical and Physical Properties

Specific Rotation[α]117.5 ° (C=1, H2O)
Melt Point(°C)250°C(dec.)(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H360:May damage fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

RTECS NZ3225030
Reaxy-Rn 3874279
Class 6.1
Merck Index 5281

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Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173).  [PMID:38126652]
2. Jun Yao.  (2024)  A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2.  ANALYTICA CHIMICA ACTA,  1288  (342141).  [PMID:38220276]
3. Yin Bao, Kaiwei Cai, Yichen Liu, Bingling Li.  (2023)  Aptamer-Based Antibiotic Electrochemical Detection Platform Using Portable Plastic Gold Electrode and Multichannel Chip.  CHINESE JOURNAL OF CHEMISTRY,    (4):   [PMID:16990800]
4. Pei Jia, Qiushuang Wu, Boyang Sun, Li Wang.  (2023)  Formic Acid-Regulated Defect Engineering in Zr-Based Metal-Organic Frameworks toward Fluorescence Sensor for Sensitive Detection of Chlortetracycline.  Small,  19  (45): (2304096).  [PMID:37415537]
5. Mingcong Rong, Yi Huang, Xiaoting Zhuang, Yingming Ma, Haijiao Xie, Yanfang Wu, Li Niu.  (2023)  AND logic-gate-based Au@MnO2 sensing platform for tetracyclines with fluorescent and colorimetric dual-signal readouts.  SENSORS AND ACTUATORS B-CHEMICAL,  393  (134204).  [PMID:]
6. Yang Zhenhua, Yang Xintong, Zhang Yuexia, Fan Xiaopeng, Cao Yujuan, Li Zhongping, Dong Chuan.  (2023)  Detection of oxytetracycline in milk using a novel carbon dots-based fluorescence probe via facile pyrolysis synthesis.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (35): (84002-84010).  [PMID:37353701]
7. Jianan Li, Wenjie Huang, Huixia He, Shuangni Shi, Xiuxia Sun, Jianxi Xiao.  (2023)  Biocompatible and bioactive hydrogels of recombinant fusion elastin with low transition temperature for improved healing of UV-irradiated skin.  Journal of Materials Chemistry B,      [PMID:37401183]
8. Yafang Liu, Ming Yi, Yan Wang.  (2023)  Boronate ester-based pH stimulated bactericide armoring for efficient fouling control of LNF membranes.  JOURNAL OF MEMBRANE SCIENCE,  678  (121662).  [PMID:]
9. Jing Han, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang.  (2023)  Study of binding mechanism of aptamer to kanamycin and the development of fluorescent aptasensor in milk detection.  TALANTA,  260  (124530).  [PMID:37116356]
10. Ming Yi, Thi Dao Nguyen, Huan Liu, Yafang Liu, Shu Xiong, Yan Wang.  (2023)  A Boronate Ester Driven Rechargeable Antibacterial Membrane for Fast Molecular Sieving.  ADVANCED FUNCTIONAL MATERIALS,  33  (26): (2213471).  [PMID:]
11. Wanling Cui, Jinrong Liu, Wenqi Zhao, Jiayi Zhang, Yanyan Wang, Qiang Li, Rui Wang, Mei Qiao, Shicai Xu.  (2023)  An enzyme-free and label-free fluorescent aptasensor for sensitive detection of kanamycin in milk samples based on hybridization chain reaction.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  120  (105300).  [PMID:]
12. Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou, Bang-Ce Ye.  (2023)  Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.  Cell Host & Microbe,  31  (199-212.e5).  [PMID:36758520]
13. Baizhu Chen, Xiaoge Zhang, Lili Cheng, Xiaomei Chen, Junjie Tang, Peng Zhang, Chen Wang, Jie Liu.  (2023)  Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy.  JOURNAL OF CONTROLLED RELEASE,  353  (889).  [PMID:36528194]
14. Jian Song, Kaiyu He, Bingcong Xing, Yong Pei, Dingnan Wang, Yang Wang, Shiyan Li, Jie Li, Weiwei Huan, Yiming Zhang, Bruce. D. Hammock.  (2022)  Rapid Measurement of Residual Kanamycin Using Highly Specific Biomimetic Recognition Paper-Based Chip.  ANALYTICAL CHEMISTRY,  94  (50): (17567–17576).  [PMID:36458677]
15. Qingbin Yuan, Pingfeng Yu, Yuan Cheng, Pengxiao Zuo, Yisi Xu, Yuxiao Cui, Yi Luo, Pedro J. J. Alvarez.  (2022)  Chlorination (but Not UV Disinfection) Generates Cell Debris that Increases Extracellular Antibiotic Resistance Gene Transfer via Proximal Adsorption to Recipients and Upregulated Transformation Genes.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  56  (23): (17166–17176).  [PMID:36286344]
16. Ying Liu, Jingfeng Gao, Mingyan Zhao, Xiaoyu Fu, Yi Zhang, Haoran Zhang.  (2023)  Removal of antibiotic resistant bacteria, genes and inhibition of plasmid-mediated horizontal transfer by peroxymonosulfate: Efficiency and mechanisms.  CHEMICAL ENGINEERING JOURNAL,  453  (139728).  [PMID:]
17. Yi Zhang, Qingbo Deng, Chang Tang, Minglu Zhang, Zilong Huang, Zhifeng Cai.  (2023)  Fluorescent folic acid-capped copper nanoclusters for the determination of rifampicin based on inner filter effect.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  286  (121944).  [PMID:36228492]
18. Hui Yang, Yunlong Wei, Xiufang Yan, Chao Nie, Zhenchun Sun, Likai Hao, Xiankun Su.  (2022)  High-Efficiency Utilization of Waste Tobacco Stems to Synthesize Novel Biomass-Based Carbon Dots for Precise Detection of Tetracycline Antibiotic Residues.  Nanomaterials,  12  (18): (3241).  [PMID:36145029]
19. Zishuo Zhang, Yuanyuan Wang, Ziyin Mei, Yiming Wang, Hui Li, Shaoguang Li, Fan Xia.  (2022)  Incorporating Hydrophobic Moieties into Self-Assembled Monolayers to Enable Electrochemical Aptamer-Based Sensors Deployed Directly in a Complex Matrix.  ACS Sensors,  (9): (2615–2624).  [PMID:35998663]
20. Yuhua Zhang, Qiaojun Fang, Hongfeng Wang, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng, Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang, Xia Gao, Zheng Ying, Renjie Chai.  (2023)  Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.  Autophagy,  19  (1): (75-91).  [PMID:35471096]
21. Wang Yang, Jin Daobin, Zhang Xiaoqian, Zhao Jikuan, Hun Xu.  (2022)  Self-enhancement photoelectrochemical strategy for kanamycin determination with amino functionalized MOFs.  MICROCHIMICA ACTA,  189  (5): (1-7).  [PMID:35426050]
22. Zhiwen Li, Jiyue Zhang, Qiyao Sun, Wenwen Shi, Tingxian Tao, Yingqiang Fu.  (2022)  Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe.  NEW JOURNAL OF CHEMISTRY,  46  (9): (4226-4232).  [PMID:]
23. Xuelian Hu, Ying Guo, Jinni Zhang, Xiaohui Wang, Guozhen Fang, Shuo Wang.  (2022)  A signal-amplified ratiometric fluorescence biomimetic sensor based on the synergistic effect of IFE and AE for the visual smart monitoring of oxytetracycline.  CHEMICAL ENGINEERING JOURNAL,  433  (134499).  [PMID:]
24. Zhou Li-Jian, Guo Li-Bin, Wei Wei, Lv Zhi-Xiang, Zhang Ye-Wang.  (2021)  A Novel Chondroitin AC Lyase With Broad Substrate Specificity From Pedobacter rhizosphaerae: Cloning, Expression, and Characterization.  Frontiers in Bioengineering and Biotechnology,  (1336).  [PMID:35004658]
25. Qi Nie, Jingjing Deng, Bing Xie, Guoyue Shi, Tianshu Zhou.  (2021)  A dual-channel colorimetric and fluorescent sensor for the rapid and ultrasensitive detection of kanamycin based on gold nanoparticles-copper nanoclusters.  Analytical Methods,  13  (48): (5813-5820).  [PMID:34852031]
26. Wanling Cui, Guodong Hu, Enguang Lv, Chonghui Li, Zhenxing Wang, Qiang Li, Zhaohong Qian, Jihua Wang, Shicai Xu, Rui Wang.  (2022)  A label-free and enzyme-free fluorescent aptasensor for amplified detection of kanamycin in milk sample based on target-triggered catalytic hairpin assembly.  FOOD CONTROL,  133  (108654).  [PMID:]
27. Yimeng Sun, Cong Ma, Man Wu, Chunping Jia, Shilun Feng, Jianlong Zhao, Lijuan Liang.  (2022)  Sensitivity of photoelctrocehmical aptasensor using spiral nanorods for detecting antiobiotic levels in experimental and real samples.  TALANTA,  237  (122930).  [PMID:34736667]

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