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Kanamycin sulfate from Streptomyces kanamyceticus - powder, BioReagent, suitable for cell culture, suitable for plant cell culture, high purity , CAS No.25389-94-0

Item Number
K432461
Grouped product items
SKUSizeAvailabilityPrice Qty
K432461-1g
1g
In stock
$86.90
K432461-5g
5g
In stock
$222.90
K432461-25g
25g
In stock
$915.90
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Basic Description

SynonymsKanamycin sulfate | 25389-94-0 | Kanamycin A sulfate | Kanamycin monosulfate | Kanamycin acid sulfate | Kanamycin (sulfate) | Kanamycin A sulphate | Ophtalmokalixan | 133-92-6 | Kanamycin Monosulphate | 3847-27-6 | J80EX28SMQ | Kanamycin monosulfate [JAN] | Kanamycin A monosulfate
Specifications & PurityBioReagent, for plant cell culture, powder
Biochemical and Physiological MechanismsMode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can
GradeBioReagent, for plant cell culture
Note注意: Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
Product Description

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus . It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100μg/mL. Chemical structure: aminoglycoside


Application

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Tyrosyl-DNA phosphodiesterase 1 345557 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Histone deacetylase 6 222 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Streptococcus pneumoniae 31063 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Pseudomonas aeruginosa 123386 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Klebsiella pneumoniae 43867 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Proteus vulgaris 5823 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Micrococcus luteus 7463 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Staphylococcus aureus 210822 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Staphylococcus epidermidis 22802 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Escherichia coli 133304 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Proteus mirabilis 3894 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Salmonella 646 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Salmonella enteritidis 727 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Serratia marcescens 3237 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Streptococcus pyogenes 16140 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Bacillus subtilis 32866 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mycobacterium tuberculosis 203094 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Enterococcus faecalis 29875 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Bacillus cereus 7522 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Candida albicans 78123 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Replicase polyprotein 1ab 378 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SARS-CoV-2 38078 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
INCHI InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChi Key OOYGSFOGFJDDHP-KMCOLRRFSA-N
Canonical SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
RTECS NZ3225030
Alternate CAS 70560-51-9
PubChem CID 441374
UN Number 2811
Packing Group III
Molecular Weight 582.58
Beilstein 18(4)7631
Reaxy-Rn 3874279

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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6 results found

Lot NumberCertificate TypeDateItem
G2301535Certificate of AnalysisJun 17, 2023 K432461
G2301536Certificate of AnalysisJun 17, 2023 K432461
G2301539Certificate of AnalysisJun 17, 2023 K432461
G2301542Certificate of AnalysisJun 17, 2023 K432461
G2301543Certificate of AnalysisJun 17, 2023 K432461
G2301544Certificate of AnalysisJun 17, 2023 K432461

Chemical and Physical Properties

SolubilityH2O: 10-50mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)
Specific Rotation[α]117.5 ° (C=1, H2O)
Melt Point(°C)250°C(dec.)(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H360:May damage fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

RTECS NZ3225030
Reaxy-Rn 3874279
Class 6.1
Merck Index 5281

Related Documents

 SDS

 Specification Sheet

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FAQs and Articles

FAQ
Antibiotics block bacterial protein synthesis
Categories: Technical articles
Tags:
Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture
E. coli Competence Protocol for Plasmid Transformation
Categories: Protocols
Tags:
Antibiotics Microbiology Molecular Biology Plasmid transformation Vector construction E·coli competent cells Microbial medium raw materials Laboratory chemicals

Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173).  [PMID:38126652]
2. Jun Yao.  (2024)  A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2.  ANALYTICA CHIMICA ACTA,  1288  (342141).  [PMID:38220276]
3. Yin Bao, Kaiwei Cai, Yichen Liu, Bingling Li.  (2023)  Aptamer-Based Antibiotic Electrochemical Detection Platform Using Portable Plastic Gold Electrode and Multichannel Chip.  CHINESE JOURNAL OF CHEMISTRY,    (4):   [PMID:16990800]
4. Pei Jia, Qiushuang Wu, Boyang Sun, Li Wang.  (2023)  Formic Acid-Regulated Defect Engineering in Zr-Based Metal-Organic Frameworks toward Fluorescence Sensor for Sensitive Detection of Chlortetracycline.  Small,  19  (45): (2304096).  [PMID:37415537]
5. Mingcong Rong, Yi Huang, Xiaoting Zhuang, Yingming Ma, Haijiao Xie, Yanfang Wu, Li Niu.  (2023)  AND logic-gate-based Au@MnO2 sensing platform for tetracyclines with fluorescent and colorimetric dual-signal readouts.  SENSORS AND ACTUATORS B-CHEMICAL,  393  (134204).  [PMID:]
6. Yang Zhenhua, Yang Xintong, Zhang Yuexia, Fan Xiaopeng, Cao Yujuan, Li Zhongping, Dong Chuan.  (2023)  Detection of oxytetracycline in milk using a novel carbon dots-based fluorescence probe via facile pyrolysis synthesis.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (35): (84002-84010).  [PMID:37353701]
7. Jianan Li, Wenjie Huang, Huixia He, Shuangni Shi, Xiuxia Sun, Jianxi Xiao.  (2023)  Biocompatible and bioactive hydrogels of recombinant fusion elastin with low transition temperature for improved healing of UV-irradiated skin.  Journal of Materials Chemistry B,      [PMID:37401183]
8. Ming Yi, Thi Dao Nguyen, Huan Liu, Yafang Liu, Shu Xiong, Yan Wang.  (2023)  A Boronate Ester Driven Rechargeable Antibacterial Membrane for Fast Molecular Sieving.  ADVANCED FUNCTIONAL MATERIALS,  33  (26): (2213471).  [PMID:]
9. Wanling Cui, Jinrong Liu, Wenqi Zhao, Jiayi Zhang, Yanyan Wang, Qiang Li, Rui Wang, Mei Qiao, Shicai Xu.  (2023)  An enzyme-free and label-free fluorescent aptasensor for sensitive detection of kanamycin in milk samples based on hybridization chain reaction.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  120  (105300).  [PMID:]
10. Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou, Bang-Ce Ye.  (2023)  Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.  Cell Host & Microbe,  31  (199-212.e5).  [PMID:36758520]
11. Baizhu Chen, Xiaoge Zhang, Lili Cheng, Xiaomei Chen, Junjie Tang, Peng Zhang, Chen Wang, Jie Liu.  (2023)  Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy.  JOURNAL OF CONTROLLED RELEASE,  353  (889).  [PMID:36528194]
12. Jian Song, Kaiyu He, Bingcong Xing, Yong Pei, Dingnan Wang, Yang Wang, Shiyan Li, Jie Li, Weiwei Huan, Yiming Zhang, Bruce. D. Hammock.  (2022)  Rapid Measurement of Residual Kanamycin Using Highly Specific Biomimetic Recognition Paper-Based Chip.  ANALYTICAL CHEMISTRY,  94  (50): (17567–17576).  [PMID:36458677]
13. Qingbin Yuan, Pingfeng Yu, Yuan Cheng, Pengxiao Zuo, Yisi Xu, Yuxiao Cui, Yi Luo, Pedro J. J. Alvarez.  (2022)  Chlorination (but Not UV Disinfection) Generates Cell Debris that Increases Extracellular Antibiotic Resistance Gene Transfer via Proximal Adsorption to Recipients and Upregulated Transformation Genes.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  56  (23): (17166–17176).  [PMID:36286344]
14. Ying Liu, Jingfeng Gao, Mingyan Zhao, Xiaoyu Fu, Yi Zhang, Haoran Zhang.  (2023)  Removal of antibiotic resistant bacteria, genes and inhibition of plasmid-mediated horizontal transfer by peroxymonosulfate: Efficiency and mechanisms.  CHEMICAL ENGINEERING JOURNAL,  453  (139728).  [PMID:]
15. Zishuo Zhang, Yuanyuan Wang, Ziyin Mei, Yiming Wang, Hui Li, Shaoguang Li, Fan Xia.  (2022)  Incorporating Hydrophobic Moieties into Self-Assembled Monolayers to Enable Electrochemical Aptamer-Based Sensors Deployed Directly in a Complex Matrix.  ACS Sensors,  7  (9): (2615–2624).  [PMID:35998663]
16. Yuhua Zhang, Qiaojun Fang, Hongfeng Wang, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng, Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang, Xia Gao, Zheng Ying, Renjie Chai.  (2023)  Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.  Autophagy,  19  (1): (75-91).  [PMID:35471096]
17. Wang Yang, Jin Daobin, Zhang Xiaoqian, Zhao Jikuan, Hun Xu.  (2022)  Self-enhancement photoelectrochemical strategy for kanamycin determination with amino functionalized MOFs.  MICROCHIMICA ACTA,  189  (5): (1-7).  [PMID:35426050]
18. Xuelian Hu, Ying Guo, Jinni Zhang, Xiaohui Wang, Guozhen Fang, Shuo Wang.  (2022)  A signal-amplified ratiometric fluorescence biomimetic sensor based on the synergistic effect of IFE and AE for the visual smart monitoring of oxytetracycline.  CHEMICAL ENGINEERING JOURNAL,  433  (134499).  [PMID:]
19. Zhou Li-Jian, Guo Li-Bin, Wei Wei, Lv Zhi-Xiang, Zhang Ye-Wang.  (2021)  A Novel Chondroitin AC Lyase With Broad Substrate Specificity From Pedobacter rhizosphaerae: Cloning, Expression, and Characterization.  Frontiers in Bioengineering and Biotechnology,  9  (1336).  [PMID:35004658]
20. Qi Nie, Jingjing Deng, Bing Xie, Guoyue Shi, Tianshu Zhou.  (2021)  A dual-channel colorimetric and fluorescent sensor for the rapid and ultrasensitive detection of kanamycin based on gold nanoparticles-copper nanoclusters.  Analytical Methods,  13  (48): (5813-5820).  [PMID:34852031]
21. Wanling Cui, Guodong Hu, Enguang Lv, Chonghui Li, Zhenxing Wang, Qiang Li, Zhaohong Qian, Jihua Wang, Shicai Xu, Rui Wang.  (2022)  A label-free and enzyme-free fluorescent aptasensor for amplified detection of kanamycin in milk sample based on target-triggered catalytic hairpin assembly.  FOOD CONTROL,  133  (108654).  [PMID:]

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