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Kartogenin - ≥98% (HPLC), high purity , CAS No.4727-31-5 3 Citations
Promotes differentiation of human mesenchymal stems cells into chondrocytes
Basic Description Synonyms KGN | 2-[[1,1'-Biphenyl]-4-ylcarbamoyl]benzoic Acid | 2-[(Biphenyl-4-yl)carbamoyl]benzoic acid | 4'-Phenyl-phthalanilic acid (8CI) Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, k Storage Temp Store at 2-8°C,Argon charged Shipped In Wet ice Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[(4-phenylphenyl)carbamoyl]benzoic acid INCHI InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) InChi Key SLUINPGXGFUMLL-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)O Isomeric SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)O WGK Germany 3 PubChem CID 2826191 Molecular Weight 317.34
Chemical and Physical Properties Solubility DMSO: >15 mg/mL Sensitivity Air sensitive，Heat sensitive Melt Point(°C) 278 °C
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3
Citations of This Product 1. Lang Bai, Qibin Han, Zeyu Han, Xiaoyu Zhang, Jingwen Zhao, Huitong Ruan, Junliang Wang, Feng Lin, Wenguo Cui, Xing Yang, Yuefeng Hao. (2023) Stem Cells Expansion Vector via Bioadhesive Porous Microspheres for Accelerating Articular Cartilage Regeneration. Advanced Healthcare Materials, (2302327). [PMID:37947298 ] 2. Gang Wei, Yubin Yao, Hongbo Zhang, Wenguo Cui, Yong Lu. (2023) Cage-shaped silsesquioxane with multiactive sites for impeding aggregation of small insoluble organic molecule. CHEMICAL ENGINEERING JOURNAL, 470 (144330). [PMID: 3. Zhang Hanyuan, Fang Weijun, Zhao Tingting, Zhang Huabing, Gao Liang, Li Jingya, Wang Rujing, Xu Weiping. (2022) Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35935481 ]
References 1. Lang Bai, Qibin Han, Zeyu Han, Xiaoyu Zhang, Jingwen Zhao, Huitong Ruan, Junliang Wang, Feng Lin, Wenguo Cui, Xing Yang, Yuefeng Hao. (2023) Stem Cells Expansion Vector via Bioadhesive Porous Microspheres for Accelerating Articular Cartilage Regeneration. Advanced Healthcare Materials, (2302327). [PMID:37947298 ] 2. Gang Wei, Yubin Yao, Hongbo Zhang, Wenguo Cui, Yong Lu. (2023) Cage-shaped silsesquioxane with multiactive sites for impeding aggregation of small insoluble organic molecule. CHEMICAL ENGINEERING JOURNAL, 470 (144330). [PMID: 3. Zhang Hanyuan, Fang Weijun, Zhao Tingting, Zhang Huabing, Gao Liang, Li Jingya, Wang Rujing, Xu Weiping. (2022) Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35935481 ]
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