Click Here for 5% Off Your First Aladdin Purchase!

Ketoconazole - ≥98%, high purity , CAS No.65277-42-1, Inhibitor of CYP3A4;Channel blocker of K v1.8

Specifications & Purity:  ≥98%
Item Number
K129737
Grouped product items
SKUSizeAvailabilityPrice Qty
K129737-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$128.90
K129737-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$441.90
K129737-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$795.90
K129737-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,790.90
K129737-100g
100g
In stock
$6,444.90
K129737-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$28,999.90

Potent cytochrome P450 inhibitor. Antifungal agent.

Basic Description

Synonymsketoconazole|(+)-Ketoconazole|65277-42-1|Xolegel|142128-59-4|(2R,4S)-ketoconazole|Kuric|Ketocanazole|CPD000058460|CHEMBL75|SMR000058460|MLS000069784|MLS001146934|1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]m
Specifications & Purity≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeCHANNEL BLOCKER, INHIBITOR
Mechanism of actionInhibitor of CYP3A4;Channel blocker of K v1.8

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP24A1 Tchem 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP19A1 Tclin Aromatase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP17A1 Tclin Steroid 17-alpha-hydroxylase/17,20 lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNA10 Tclin Potassium voltage-gated channel subfamily A member 10 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
INCHI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
InChi Key XMAYWYJOQHXEEK-OZXSUGGESA-N
Canonical SMILES CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
Isomeric SMILES CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
WGK Germany 3
RTECS TK7912300
PubChem CID 456201
Molecular Weight 531.43
Reaxy-Rn 5488107

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot NumberCertificate TypeDateItem
G2227239Certificate of AnalysisMay 20, 2024 K129737
G2227241Certificate of AnalysisMay 20, 2024 K129737
G2227242Certificate of AnalysisMay 20, 2024 K129737
G2227270Certificate of AnalysisMay 20, 2024 K129737
G2227240Certificate of AnalysisMay 13, 2024 K129737
D2422220Certificate of AnalysisMar 25, 2024 K129737
F2125353Certificate of AnalysisApr 13, 2023 K129737
F2125352Certificate of AnalysisApr 13, 2023 K129737
F2125354Certificate of AnalysisApr 13, 2023 K129737
H2005074Certificate of AnalysisJun 17, 2022 K129737
G2311055Certificate of AnalysisJun 15, 2022 K129737
H2311033Certificate of AnalysisJun 15, 2022 K129737
I2311025Certificate of AnalysisJun 15, 2022 K129737

more

Chemical and Physical Properties

SolubilitySoluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg/mL), and methanol
Sensitivityheat sensitive
Melt Point(°C)150 °C

Safety and Hazards(GHS)

Pictogram(s) GHS06,GHS08,GHS09
Signal Danger
Hazard Statements H301,H373,H400,H410,H360F
Precautionary Statements P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P203,P301+P316,P318,P319
WGK Germany 3
RTECS TK7912300
Reaxy-Rn 5488107
Merck Index 5302

Related Documents

Product Questions

Product Questions

Sign In Hover me Please sign in to submit a question
No questions yet. Be the first to ask the question!

Reviews

Customer Reviews

References

1. Islam M et al..  (2018)  Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy..  Cell Death Dis,  (2): (239).  [PMID:29445159]

Calculator