Calculate the mass, volume, or concentration required for a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K129737-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $128.90 | |
K129737-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $441.90 | |
K129737-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $795.90 | |
K129737-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,790.90 | |
K129737-100g | 100g | In stock | $6,444.90 | |
K129737-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $28,999.90 |
Potent cytochrome P450 inhibitor. Antifungal agent.
Synonyms | ketoconazole|(+)-Ketoconazole|65277-42-1|Xolegel|142128-59-4|(2R,4S)-ketoconazole|Kuric|Ketocanazole|CPD000058460|CHEMBL75|SMR000058460|MLS000069784|MLS001146934|1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]m |
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Specifications & Purity | ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Inhibitor of CYP3A4;Channel blocker of K v1.8 |
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IUPAC Name | 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone |
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INCHI | InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 |
InChi Key | XMAYWYJOQHXEEK-OZXSUGGESA-N |
Canonical SMILES | CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
Isomeric SMILES | CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
WGK Germany | 3 |
RTECS | TK7912300 |
PubChem CID | 456201 |
Molecular Weight | 531.43 |
Reaxy-Rn | 5488107 |
PubChem CID | 3823 |
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ChEBI | CHEBI:48339 |
BindingDB Ligand | 8610 |
DrugBank Ligand | DB01026 |
Wikipedia | Ketoconazole |
CAS Registry No. | 65277-42-1 |
ChEMBL Ligand | CHEMBL157101 |
DrugCentral Ligand | 1527 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | May 20, 2024 | K129737 | |
Certificate of Analysis | May 20, 2024 | K129737 | |
Certificate of Analysis | May 20, 2024 | K129737 | |
Certificate of Analysis | May 20, 2024 | K129737 | |
Certificate of Analysis | May 13, 2024 | K129737 | |
Certificate of Analysis | Mar 25, 2024 | K129737 | |
Certificate of Analysis | Apr 13, 2023 | K129737 | |
Certificate of Analysis | Apr 13, 2023 | K129737 | |
Certificate of Analysis | Apr 13, 2023 | K129737 | |
Certificate of Analysis | Jun 17, 2022 | K129737 | |
Certificate of Analysis | Jun 15, 2022 | K129737 | |
Certificate of Analysis | Jun 15, 2022 | K129737 | |
Certificate of Analysis | Jun 15, 2022 | K129737 |
Solubility | Soluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg/mL), and methanol |
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Sensitivity | heat sensitive |
Melt Point(°C) | 150 °C |
Pictogram(s) | GHS06,GHS08,GHS09 |
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Signal | Danger |
Hazard Statements | H301,H373,H400,H410,H360F |
Precautionary Statements | P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P203,P301+P316,P318,P319 |
WGK Germany | 3 |
RTECS | TK7912300 |
Reaxy-Rn | 5488107 |
Merck Index | 5302 |
1. Islam M et al.. (2018) Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy.. Cell Death Dis, 9 (2): (239). [PMID:29445159] |