Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K129331-5g | 5g | In stock | $103.90 | |
K129331-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $187.90 | |
K129331-25g | 25g | In stock | $421.90 | |
K129331-100g | 100g | In stock | $1,516.90 | |
K129331-250g | 250g | In stock | $3,411.90 | |
K129331-500g | 500g | In stock | $6,141.90 |
Non-selective COX inhibitor
Synonyms | DTXSID6020771 | Iso-K | Ketoprofenum [INN-Latin] | Acide (benzoyl-3-phenyl)-2-propionique | KetoMed | KETOPROFEN [JAN] | L'Acide (benzoyl-3-phenyl)-2-propionique | R.P. 19583 | NSC 758144 | Toprek | Alrheumat | Propionic acid, 2-(3-benzoylphenyl)- | rac K |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Ketoprofen is a non-selective NSAID which inhibits both human recombinant Cox-1 (IC50 of 0.5 μM) and Cox-2 (IC50 of 2.33 μM). Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting Cox-1 and Cox-2 (cyclooxygenase |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. |
ALogP | 3.1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179798 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179798 |
IUPAC Name | 2-(3-benzoylphenyl)propanoic acid |
INCHI | InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) |
InChi Key | DKYWVDODHFEZIM-UHFFFAOYSA-N |
Canonical SMILES | CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O |
Isomeric SMILES | CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O |
WGK Germany | 3 |
RTECS | UE7570000 |
PubChem CID | 3825 |
Molecular Weight | 254.28 |
Reaxy-Rn | 2216071 |
DrugBank Ligand | DB01009 |
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Wikipedia | Ketoprofen |
ChEBI | CHEBI:6128 |
CAS Registry No. | 22071-15-4 |
ChEMBL Ligand | CHEMBL571 |
PubChem CID | 3825 |
PEP | ketoprofen |
DrugCentral Ligand | 1528 |
PubChem SID | 488179798 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2317899 | Certificate of Analysis | Dec 05, 2024 | K129331 |
B2317927 | Certificate of Analysis | Dec 05, 2024 | K129331 |
B2318172 | Certificate of Analysis | Dec 05, 2024 | K129331 |
B2317898 | Certificate of Analysis | Dec 05, 2024 | K129331 |
F23131113 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131231 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131230 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131229 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131119 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131118 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131071 | Certificate of Analysis | May 29, 2023 | K129331 |
F23131070 | Certificate of Analysis | May 29, 2023 | K129331 |
G2123241 | Certificate of Analysis | May 10, 2023 | K129331 |
B2317903 | Certificate of Analysis | Dec 20, 2022 | K129331 |
B2317902 | Certificate of Analysis | Dec 20, 2022 | K129331 |
B2317901 | Certificate of Analysis | Dec 20, 2022 | K129331 |
K2210239 | Certificate of Analysis | Nov 11, 2022 | K129331 |
L2009182 | Certificate of Analysis | Oct 17, 2022 | K129331 |
K1826111 | Certificate of Analysis | Jul 13, 2022 | K129331 |
Solubility | Soluble in ethanol (51 mg/ml at 25 °C), DMSO (51 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), DMF (≥20 mg/ml), and PBS (pH 7.2) (≥0.5 mg/ml). |
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Sensitivity | Light sensitive |
Melt Point(°C) | 92-97° |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | UE7570000 |
Reaxy-Rn | 2216071 |
Merck Index | 5305 |
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5. Hao-Ze Li, Cheng Yang, Hai-Long Qian, Xiu-Ping Yan. (2023) Room-temperature synthesis of ionic covalent organic frameworks for efficient removal of diclofenac sodium from aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122704). [PMID:] [10.1016/j.seppur.2022.122704] |
6. Jinbo Ouyang, Jian Chen, Wenqian Chen, Limin Zhou, Di Cai, Cong Ren. (2023) H3PO4 activated biochars derived from different agricultural biomasses for the removal of ciprofloxacin from aqueous solution. Particuology, 75 (217). [PMID:] [10.1016/j.partic.2022.07.016] |
7. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng. (2022) The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 642 (128609). [PMID:] [10.1016/j.colsurfa.2022.128609] |
8. Lixiao Wang, Yajie Zheng, Yiran Zhou, Junhe Lu, Jean-Marc Chovelon, Yuefei Ji. (2022) Aquatic photolysis of ketoprofen generates products with photosensitizing activity and toxicity. WATER RESEARCH, 210 (117982). [PMID:34954366] [10.1016/j.watres.2021.117982] |
9. Jian Chen, Jinbo Ouyang, Wenqian Chen, Zepeng Zheng, Zhen Yang, Zhirong Liu, Limin Zhou. (2022) Fabrication and adsorption mechanism of chitosan/Zr-MOF (UiO-66) composite foams for efficient removal of ketoprofen from aqueous solution. CHEMICAL ENGINEERING JOURNAL, 431 (134045). [PMID:] [10.1016/j.cej.2021.134045] |
10. Ying Lu, Fujian Yang, Siyuan Chen, Wenchao Shi, Chengdu Qi, Guilong Peng. (2022) Decomplexation of Ni(II)-citrate and recovery of nickel from chelated nickel containing electroplating wastewater by peroxymonosulfate with nickel. SEPARATION AND PURIFICATION TECHNOLOGY, 283 (120142). [PMID:] [10.1016/j.seppur.2021.120142] |
11. Jian Chen, Jinbo Ouyang, Weixin Lai, Xiaohong Xing, Limin Zhou, Zhirong Liu, Wenqian Chen, Di Cai. (2021) Synthesis of ultralight chitosan/activated biochar composite aerogel globules for ketoprofen removal from aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, 279 (119700). [PMID:] [10.1016/j.seppur.2021.119700] |
12. Shan Chen, Shu Zhou, Jinli Fu, Sisi Tang, Xiaodan Wu, Pengfei Zhao, Zhaohui Zhang. (2021) A near infrared fluorescence imprinted sensor based on zinc oxide nanorods for rapid determination of ketoprofen. Analytical Methods, 13 (25): (2836-2846). [PMID:34080589] [10.1039/D1AY00555C] |
13. Xu Xu, Feng Xue, Liu Zhen, Xue Shan, Zhang Lei. (2021) 3D flower-liked Fe3O4/C for highly sensitive magnetic dispersive solid-phase extraction of four trace non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 188 (2): (1-10). [PMID:33496871] [10.1007/s00604-021-04708-1] |
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24. Xuemei Wang, Wei Zhou, Chenlu Wang, Zilin Chen. (2018) Cotton fiber-supported layered double hydroxides for the highly efficient adsorption of anionic organic pollutants in water. NEW JOURNAL OF CHEMISTRY, 42 (12): (9463-9471). [PMID:] [10.1039/C8NJ00678D] |
25. Wang Tong, Wu Hai-Long, Xie Li-Xia, Liu Zhi, Long Wan-Jun, Cheng Li, Ding Yu-Jie, Yu Ru-Qin. (2018) Simultaneous and interference-free determination of eleven non-steroidal anti-inflammatory drugs illegally added into Chinese patent drugs using chemometrics-assisted HPLC-DAD strategy. Science China-Chemistry, 61 (6): (739-749). [PMID:] [10.1007/s11426-017-9210-8] |
26. Xue Shu-Wen, Li Jing, Xu Li. (2017) Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (12): (3103-3113). [PMID:28224244] [10.1007/s00216-017-0251-8] |
27. Ning Zhuo, Yaqian Lan, Weiben Yang, Zhen Yang, Xiaomin Li, Xia Zhou, Yang Liu, Jiachun Shen, Xuntong Zhang. (2017) Adsorption of three selected pharmaceuticals and personal care products (PPCPs) onto MIL-101(Cr)/natural polymer composite beads. SEPARATION AND PURIFICATION TECHNOLOGY, 177 (272). [PMID:] [10.1016/j.seppur.2016.12.041] |
28. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [PMID:] [10.1007/s00604-015-1638-x] |
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26. Xue Shu-Wen, Li Jing, Xu Li. (2017) Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (12): (3103-3113). [PMID:28224244] [10.1007/s00216-017-0251-8] |
27. Ning Zhuo, Yaqian Lan, Weiben Yang, Zhen Yang, Xiaomin Li, Xia Zhou, Yang Liu, Jiachun Shen, Xuntong Zhang. (2017) Adsorption of three selected pharmaceuticals and personal care products (PPCPs) onto MIL-101(Cr)/natural polymer composite beads. SEPARATION AND PURIFICATION TECHNOLOGY, 177 (272). [PMID:] [10.1016/j.seppur.2016.12.041] |
28. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [PMID:] [10.1007/s00604-015-1638-x] |