KH 7 - 98%, high purity , CAS No.330676-02-3, Inhibitor of adenylyl cyclase 10

Item Number

K287947

Grouped product items
SKU	Size	Availability	Price
K287947-10mg	10mg	In stock	$157.90
K287947-50mg	50mg	In stock	$543.90
K287947-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,448.90

Selective soluble adenylyl cyclase inhibitor

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Basic Description

Synonyms	1613631-72-3 \| ( inverted exclamation markA)-2-(1H-benziMidazol-2-ylthio)propanoicacid2-[(5-broMo-2-hydroxyphenyl)Methylene]hydrazide \| HMS3648I20 \| 2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]propanamide \| 2-(1H-benz
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of adenylyl cyclase 10
Product Description	KH7 has been used: as a soluble adenyl cyclase (sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient receptor type 1 (TRPV1) in sperm cells. as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells. as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).

Names and Identifiers

IUPAC Name	2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]propanamide
INCHI	InChI=1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,23H,1H3,(H,20,21)(H,22,24)/b19-9+
InChi Key	WILMXUAKQKGGCC-DJKKODMXSA-N
Canonical SMILES	CC(C(=O)NN=CC1=C(C=CC(=C1)Br)O)SC2=NC3=CC=CC=C3N2
Isomeric SMILES	CC(C(=O)N/N=C/C1=C(C=CC(=C1)Br)O)SC2=NC3=CC=CC=C3N2
PubChem CID	135496218
Molecular Weight	419.3

PubChem CID

CAS Registry No.

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
K2103846	Certificate of Analysis	Aug 19, 2024	K287947
K2103847	Certificate of Analysis	Aug 19, 2024	K287947
K2103850	Certificate of Analysis	Aug 19, 2024	K287947

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
RIDADR	UN28116.1/PGIII

References

1. Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS et al.. (2005) The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.. Dev Cell, 9 (2): (249-59). [PMID:16054031] [10.1021/op500134e]

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Basic Description