Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K125637-5mg | 5mg | In stock | $86.90 | |
K125637-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $391.90 | |
K125637-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $959.90 |
CaM kinase II inhibitor. P2X 7 antagonist.
Synonyms | KN62 | KN-62 | MFCD00083180 | NCGC00162398-03 | [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate. | Ponceau BNA | [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-pheny |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 μM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 μM of KN-62 blocked C |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of P2X7 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM. |
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IUPAC Name | [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate |
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INCHI | InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1 |
InChi Key | RJVLFQBBRSMWHX-DHUJRADRSA-N |
Canonical SMILES | CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7 |
Isomeric SMILES | CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7 |
WGK Germany | 3 |
PubChem CID | 5312126 |
Molecular Weight | 721.84 |
PubChem CID | 5312126 |
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CAS Registry No. | 127191-97-3 |
ChEMBL Ligand | CHEMBL28324 |
Wikipedia | KN-62 |
Enter Lot Number to search for COA:
Solubility | DMSO |
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WGK Germany | 3 |
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1. Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H. (1990) KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.. J Biol Chem, 265 (8): (4315-20). [PMID:2155222] [10.1021/op500134e] |
2. Chessell IP, Michel AD, Humphrey PP. (1998) Effects of antagonists at the human recombinant P2X7 receptor.. Br J Pharmacol, 124 (6): (1314-20). [PMID:9720806] [10.1021/op500134e] |
3. Wu K et al.. (2021) Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.. Cell Rep, 34 (12): (108899). [PMID:33761345] |
4. Glasgow SD et al.. (2018) Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.. Cell Rep, 25 (168-182.e6). [PMID:30282026] |
5. Jing L et al.. (2015) Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms.. Sci Rep, 5 (15000). [PMID:26449319] |
6. Luchkina NV et al.. (2014) Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors.. Proc Natl Acad Sci U S A, 111 (11): (4321-6). [PMID:24599589] |