Kobe0065 - 10mM in DMSO, high purity , CAS No.436133-68-5

Item Number

K423962

Grouped product items
SKU	Size	Availability	Price	Qty
K423962-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$184.90

Small molecule inhibitor of the H-Ras-c-Raf1 interaction

Basic Description

Synonyms	Kobe0065 \| 436133-68-5 \| Kobe-0065 \| Kobe 0065 \| N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide \| 1-(3-chloro-4-methylphenyl)-3-[2,6-dinitro-4-(trifluoromethyl)anilino]thiourea \| N-(3-chloro-4-methylphenyl)-2-(2,6-dinitr
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Kobe0065 is small molecule inhibitor of the H-Ras-c-Raf interaction. It competitively inhibits the binding of H-Ras•GTD to c-Raf1 RBD with an IC 50 of 46\xa0μM. Exhibits antiproliferative activity in xenografts of SW480 colon carcinoma cells carrying the
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions.

Associated Targets(Human)

HRAS Tchem Transforming protein p21/H-Ras-1 (138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW480 (6023 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-(3-chloro-4-methylphenyl)-3-[2,6-dinitro-4-(trifluoromethyl)anilino]thiourea
INCHI	InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
InChi Key	KSJVAYBCXSURMQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl
Isomeric SMILES	CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl
PubChem CID	3827663
Molecular Weight	449.79

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P301:IF SWALLOWED: P330:Rinse mouth.

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Basic Description