Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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K140848-25g | 25g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $64.90 | |
K140848-100g | 100g | In stock | $232.90 | |
K140848-250g | 250g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $523.90 | |
K140848-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $551.90 |
Synonyms | AI3-02549 | HSDB 7664 | CS-0032701 | KOJIC ACID (MART.) | 2-HYDROXYMETHYL-5-HYDROXY-.GAMMA.-PYRONE | 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone | HMS502O05 | BIDD:ER0501 | NCGC00168903-01 | InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | NCGC00017325- |
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Specifications & Purity | ≥97% |
Shipped In | Normal |
Product Description | Tyrosinase inhibitor |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5-hydroxy-2-(hydroxymethyl)pyran-4-one |
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INCHI | InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 |
InChi Key | BEJNERDRQOWKJM-UHFFFAOYSA-N |
Canonical SMILES | C1=C(OC=C(C1=O)O)CO |
Isomeric SMILES | C1=C(OC=C(C1=O)O)CO |
WGK Germany | 3 |
RTECS | UQ0875000 |
PubChem CID | 3840 |
Molecular Weight | 142.11 |
Beilstein | 120895 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2423159 | Certificate of Analysis | Jul 01, 2024 | K140848 |
E2322607 | Certificate of Analysis | May 27, 2023 | K140848 |
H2229644 | Certificate of Analysis | Sep 02, 2022 | K140848 |
H2423020 | Certificate of Analysis | Sep 02, 2022 | K140848 |
E2217150 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217153 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217154 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217162 | Certificate of Analysis | May 24, 2022 | K140848 |
L2410087 | Certificate of Analysis | May 24, 2022 | K140848 |
A2219146 | Certificate of Analysis | Feb 15, 2022 | K140848 |
Solubility | Soluble in water, acetone (freely soluble), ethanol (freely soluble), methanol, DMSO, ethyl acetate (slightly soluble), chloroform (slightly soluble), pydidine (slightly soluble), and ether (slightly soluble). Insoluble in benzene. |
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Melt Point(°C) | 154°C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H351:Suspected of causing cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | UQ0875000 |
Merck Index | 5317 |
1. Yilin Lin, Ruifei Wang, Xiaoqing Li, Keren Agyekumwaa Addo, Meimei Fang, Yehui Zhang, Yigang Yu. (2024) Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis. Food Science and Human Wellness, 13 (18): (736). [PMID:28525742] [10.26599/FSHW.2022.9250063] |
2. Jin Chen, Zhuangwei Zhang, Huihui Li, Hongjin Tang. (2023) Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126451). [PMID:37619686] [10.1016/j.ijbiomac.2023.126451] |
3. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI. (2023) Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 51 (100303). [PMID:] [10.1016/j.cjac.2023.100303] |
4. Xiufang Yan, Xiaoyu Ma, Daoxin Dai, Xiaojuan Yan, Xingyan Han, Xijun Bao, Qiufang Xie. (2023) Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism. Journal of Cosmetic Dermatology, 23 (1): (244-255). [PMID:37430475] [10.1111/jocd.15887] |
5. Yue Li, Xin-Xin Jiang, Hong-Mei Liu, Xiao-wei Li, Xiao-Jun Luo, Xun Liao, Yan Zhao. (2023) Covalent immobilization of tyrosinase on magnetic multi-walled carbon nanotubes for inhibitor screening. JOURNAL OF SEPARATION SCIENCE, 46 (14): (2300195). [PMID:37232227] [10.1002/jssc.202300195] |
6. De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao. (2023) Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity. NATURAL PRODUCT RESEARCH, [PMID:37161750] [10.1080/14786419.2023.2211215] |
7. Min He, Meiyan Fan, Wei Yang, Zhiyun Peng, Guangcheng Wang. (2023) Novel kojic acid-1,2,4-triazine hybrids as anti-tyrosinase agents: Synthesis, biological evaluation, mode of action, and anti-browning studies. FOOD CHEMISTRY, 419 (136047). [PMID:37018861] [10.1016/j.foodchem.2023.136047] |
8. Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen. (2023) A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation. JOURNAL OF MOLECULAR STRUCTURE, 1283 (135288). [PMID:] [10.1016/j.molstruc.2023.135288] |
9. Qin-Tao Zhou, Peng-Yun Yang, Quan-Yu Yang, Wen-Hui Pang, Xiao-Li Li, Xing-Jie Zhang, Rui-Han Zhang, Wei-Lie Xiao. (2023) Chemical Constituents of the Branches and Leaves of Picrasma chinensis P.Y. Chen and Tyrosinase Inhibiting Activity. CHEMISTRY & BIODIVERSITY, 20 (3): (e202201171). [PMID:36691852] [10.1002/cbdv.202201171] |
10. Wenfu Hou, Yile Lin, Yujie Zhang, Tingting Liu, Juan Du, Yang Yi, Hongxun Wang. (2023) Effects of kojic acid on changes in the microstructure and myofibrillar protein of duck meat during superchilled storage. JOURNAL OF FOOD SCIENCE, 88 (3): (977-987). [PMID:36650660] [10.1111/1750-3841.16448] |
11. Dechan Lu, Qun Zhang, Zufang Huang, Yudong Lu, Shangyuan Feng, Ruiyun You, Minling Li, Shaoqin Zhang. (2022) Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard. COLLOIDS AND SURFACES B-BIOINTERFACES, 217 (112645). [PMID:35780613] [10.1016/j.colsurfb.2022.112645] |
12. Yue Zheng, Lei Zhao, Junjie Yi. (2022) Phytochemical Characterization and Antioxidant and Enzyme Inhibitory Activities of Different Parts of Prinsepia utilis Royle. JOURNAL OF FOOD QUALITY, 2022 (9739851). [PMID:] [10.1155/2022/9739851] |
13. Zhao Yan, Hu Jin-Jie, Bai Xiao-Lin, Liu Hao-Peng, Qi Xu-Wei, Liao Xun. (2022) Fast screening of tyrosinase inhibitors from traditional Chinese medicinal plants by ligand fishing in combination with in situ fluorescent assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (6): (2265-2273). [PMID:34982177] [10.1007/s00216-021-03864-w] |
14. Xiang Liu, Jinqiu Rao, Kai Wang, Meijun Wang, Tie Yao, Feng Qiu. (2021) Highly Potent Inhibition of Tyrosinase by Mulberrosides and the Inhibitory Mechanism in Vitro. CHEMISTRY & BIODIVERSITY, 19 (1): (e202100740). [PMID:34752017] [10.1002/cbdv.202100740] |
15. Wenhui Zeng, Bingrong Liu, Wenjing Wu, Shijun Zhang, Yong Chen, Zhiqiang Li. (2021) Collaborative Response of the Host and Symbiotic Lignocellulytic System to Non-Lethal Toxic Stress in Coptotermes formosanus Skiraki. Insects, 12 (6): (510). [PMID:34073040] [10.3390/insects12060510] |
16. Fei Qu, QianQian Fa, Tian Yin, Dafeng Jiang, Xian-en Zhao. (2021) Aggregation-induced emission of lead halide perovskites modulated by dispersed/aggregated gold nanoparticles for application in the detection of dopamine. MATERIALS RESEARCH BULLETIN, 142 (111405). [PMID:] [10.1016/j.materresbull.2021.111405] |
17. Chen Jianmin, Ran Mengnan, Wang Meixia, Liu Xinying, Liu Siwan, Yu Yue. (2021) Structure–activity relationships of antityrosinase and antioxidant activities of cinnamic acid and its derivatives. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85 (7): (1697-1705). [PMID:33974002] [10.1093/bbb/zbab084] |
18. Jianmin Chen, Mengnan Ran, Meixia Wang, Xinying Liu, Siwan Liu, Zhipeng Ruan, Nan Jin. (2021) Evaluation of antityrosinase activity and mechanism, antioxidation, and UV filter properties of theaflavin. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 69 (3): (951-962). [PMID:33878231] [10.1002/bab.2166] |
19. Sizhu Tian, Xuwen Li, Shuang Zang, Yongri Jin, Ziwei Zhang, Yong Yu. (2020) α-Amylase and tyrosinase inhibitory activities, phenolic contents, and antioxidant capacities of wild and cultivated blueberries. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 45 (1): (e15087). [PMID:] [10.1111/jfpp.15087] |
20. Renren Sun, Haixia He, Yameng Wan, Liyuan Li, Jiao Sha, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Kojic acid in fourteen mono-solvents: Solubility data, Hansen solubility parameter and thermodynamic properties. JOURNAL OF CHEMICAL THERMODYNAMICS, 152 (106280). [PMID:] [10.1016/j.jct.2020.106280] |
21. Wenfu Hou, Qiqi Yue, Wen Liu, Ji Wu, Yang Yi, Hongxun Wang. (2021) Characterization of spoilage bacterial communities in chilled duck meat treated by kojic acid. Food Science and Human Wellness, 10 (72). [PMID:] [10.1016/j.fshw.2020.05.015] |
22. Limin Qu, Ke Song, Qi Zhang, Jie Guo, Juan Huang. (2020) Simultaneous Determination of Six Isoflavones from Puerariae Lobatae Radix by CPE-HPLC and Effect of Puerarin on Tyrosinase Activity. MOLECULES, 25 (2): (344). [PMID:31952126] [10.3390/molecules25020344] |
23. Xiao Tian, Sen Guo, Shanshan Zhang, Peisheng Li, Tianyi Wang, Chi-Tang Ho, Min-Hsiung Pan, Naisheng Bai. (2019) Chemical characterization of main bioactive constituents in Paeonia ostii seed meal and GC-MS analysis of seed oil. JOURNAL OF FOOD BIOCHEMISTRY, 44 (1): (e13088). [PMID:31646682] [10.1111/jfbc.13088] |
24. Jianmin Chen, Qinglian Li, Yaling Ye, Ziyao Huang, Zhipeng Ruan, Nan Jin. (2020) Phloretin as both a substrate and inhibitor of tyrosinase: Inhibitory activity and mechanism. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 226 (117642). [PMID:31614273] [10.1016/j.saa.2019.117642] |
25. Sen Guo, Li Liu, Shanshan Zhang, Chuang Yang, Wenping Yue, Haoan Zhao, Chi-Tang Ho, Junfeng Du, Hai Zhang, Naisheng Bai. (2019) Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry). Food & Function, 10 (10): (6915-6926). [PMID:31588440] [10.1039/C9FO01457H] |
26. Deng Hao-Hua, Lin Xiu-Ling, He Shao-Bin, Wu Gang-Wei, Wu Wei-Hua, Yang Yu, Lin Zhen, Peng Hua-Ping, Xia Xing-Hua, Chen Wei. (2019) Colorimetric tyrosinase assay based on catechol inhibition of the oxidase-mimicking activity of chitosan-stabilized platinum nanoparticles. MICROCHIMICA ACTA, 186 (5): (1-7). [PMID:31028498] [10.1007/s00604-019-3451-4] |
27. Sha Sha Li, Bo Yin, Hong Lin Zhai, Shao Hua Lu, Jia Ying Mi. (2019) An effective approach to the quantitative analysis of skin-whitening agents in cosmetics with different substrates based on conventional UV-Vis determination. Analytical Methods, 11 (11): (1500-1507). [PMID:] [10.1039/C9AY00007K] |
28. Xiangui Ma, Wenyue Gao, Mohamed Ibrahim Halawa, Yixiang Lan, Jianping Li, Guobao Xu. (2019) Lucigenin fluorescent assay of tyrosinase activity and its inhibitor screening. SENSORS AND ACTUATORS B-CHEMICAL, 280 (41). [PMID:] [10.1016/j.snb.2018.10.044] |
29. Chenyue Zhan, Jiatian Cheng, Bowen Li, Shuailing Huang, Fang Zeng, Shuizhu Wu. (2018) A Fluorescent Probe for Early Detection of Melanoma and Its Metastasis by Specifically Imaging Tyrosinase Activity in a Mouse Model. ANALYTICAL CHEMISTRY, 90 (15): (8807–8815). [PMID:29975041] [10.1021/acs.analchem.8b00594] |
30. Jiahui Zhao, Shuang Wang, Shasha Lu, Xingfu Bao, Jian Sun, Xiurong Yang. (2018) An Enzyme Cascade-Triggered Fluorogenic and Chromogenic Reaction Applied in Enzyme Activity Assay and Immunoassay. ANALYTICAL CHEMISTRY, 90 (12): (7754–7760). [PMID:29800522] [10.1021/acs.analchem.8b01845] |
31. Huihui Li, Wei Liu, Fengyuan Zhang, Xinyue Zhu, Liqiu Huang, Haixia Zhang. (2018) Highly Selective Fluorescent Probe Based on Hydroxylation of Phenylboronic Acid Pinacol Ester for Detection of Tyrosinase in Cells. ANALYTICAL CHEMISTRY, 90 (1): (855–858). [PMID:29198104] [10.1021/acs.analchem.7b03681] |
32. Yifan Wang, Liangjin Xu, Wen Gao, Lixin Niu, Chunyue Huang, Peiming Yang, Xiao Hu. (2017) Isoprenylated Phenolic Compounds from Morus macroura as Potent Tyrosinase Inhibitors. PLANTA MEDICA, 84 (5): (336-343). [PMID:29096405] [10.1055/s-0043-121698] |
33. Le-Le Shao, Xiao-Ling Wang, Kai Chen, Xiao-Wu Dong, Li-Min Kong, De-Yin Zhao, Robert C. Hider, Tao Zhou. (2018) Novel hydroxypyridinone derivatives containing an oxime ether moiety: Synthesis, inhibition on mushroom tyrosinase and application in anti-browning of fresh-cut apples. FOOD CHEMISTRY, 242 (174). [PMID:29037675] [10.1016/j.foodchem.2017.09.054] |
34. Cuihua Lei, Xian-En Zhao, Jing Sun, Xiaolu Yan, Yue Gao, Han Gao, Shuyun Zhu, Hua Wang. (2017) A simple and novel colorimetric assay for tyrosinase and inhibitor screening using 3,3′,5,5′-tetramethylbenzidine as a chromogenic probe. TALANTA, 175 (457). [PMID:28842016] [10.1016/j.talanta.2017.07.070] |
35. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan. (2017) Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits. JOURNAL OF FOOD BIOCHEMISTRY, 41 (4): (e12377). [PMID:] [10.1111/jfbc.12377] |
36. Dong-Mei Liu, Jun-Li Yang, Wei Ha, Juan Chen, Yan-Ping Shi. (2017) Kinetics and inhibition study of tyrosinase by pressure mediated microanalysis. ANALYTICAL BIOCHEMISTRY, 525 (54). [PMID:28257907] [10.1016/j.ab.2017.02.020] |
37. Mengxia Cheng, Zilin Chen. (2016) Screening of tyrosinase inhibitors by capillary electrophoresis with immobilized enzyme microreactor and molecular docking. ELECTROPHORESIS, 38 (3-4): (486-493). [PMID:27862041] [10.1002/elps.201600367] |
38. X. E. Zhao, C. H. Lei, Y. H. Wang, F. Qu, S. Y. Zhu, H. Wang, J. M. You. (2016) A fluorometric assay for tyrosinase activity and its inhibitor screening based on graphene quantum dots. RSC Advances, 6 (76): (72670-72675). [PMID:] [10.1039/C6RA13325H] |
39. Jianmin Chen, Xiaojing Yu, Yufeng Huang. (2016) Inhibitory mechanisms of glabridin on tyrosinase. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 168 (111). [PMID:27288962] [10.1016/j.saa.2016.06.008] |
40. Ye Teng, Xiaofang Jia, Jing Li, Erkang Wang. (2015) Ratiometric Fluorescence Detection of Tyrosinase Activity and Dopamine Using Thiolate-Protected Gold Nanoclusters. ANALYTICAL CHEMISTRY, 87 (9): (4897–4902). [PMID:25846058] [10.1021/acs.analchem.5b00468] |
41. Ma Xinying, Chao Mingyong. (2014) Study on the Electrochemical Properties of Kojic Acid at a Poly(glutamic Acid)-Modified Glassy Carbon Electrode and Its Analytical Application. Food Analytical Methods, 7 (7): (1458-1464). [PMID:] [10.1007/s12161-013-9772-8] |
42. Bing-bing Sun, Li Qi, Xiao-yu Mu, Juan Qiao, Ming-lin Wang. (2013) A chiral ligand exchange CE system for monitoring inhibitory effect of kojic acid on tyrosinase. TALANTA, 116 (1121). [PMID:24148524] [10.1016/j.talanta.2013.08.028] |
43. Ting-Fu Jiang, Ting-Ting Liang, Yuan-Hong Wang, Wen-Hui Zhang, Zhi-Hua Lv. (2013) Immobilized capillary tyrosinase microreactor for inhibitor screening in natural extracts by capillary electrophoresis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 84 (36). [PMID:23806998] [10.1016/j.jpba.2013.05.023] |
44. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |
1. Yilin Lin, Ruifei Wang, Xiaoqing Li, Keren Agyekumwaa Addo, Meimei Fang, Yehui Zhang, Yigang Yu. (2024) Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis. Food Science and Human Wellness, 13 (18): (736). [PMID:28525742] [10.26599/FSHW.2022.9250063] |
2. Jin Chen, Zhuangwei Zhang, Huihui Li, Hongjin Tang. (2023) Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126451). [PMID:37619686] [10.1016/j.ijbiomac.2023.126451] |
3. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI. (2023) Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 51 (100303). [PMID:] [10.1016/j.cjac.2023.100303] |
4. Xiufang Yan, Xiaoyu Ma, Daoxin Dai, Xiaojuan Yan, Xingyan Han, Xijun Bao, Qiufang Xie. (2023) Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism. Journal of Cosmetic Dermatology, 23 (1): (244-255). [PMID:37430475] [10.1111/jocd.15887] |
5. Yue Li, Xin-Xin Jiang, Hong-Mei Liu, Xiao-wei Li, Xiao-Jun Luo, Xun Liao, Yan Zhao. (2023) Covalent immobilization of tyrosinase on magnetic multi-walled carbon nanotubes for inhibitor screening. JOURNAL OF SEPARATION SCIENCE, 46 (14): (2300195). [PMID:37232227] [10.1002/jssc.202300195] |
6. De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao. (2023) Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity. NATURAL PRODUCT RESEARCH, [PMID:37161750] [10.1080/14786419.2023.2211215] |
7. Min He, Meiyan Fan, Wei Yang, Zhiyun Peng, Guangcheng Wang. (2023) Novel kojic acid-1,2,4-triazine hybrids as anti-tyrosinase agents: Synthesis, biological evaluation, mode of action, and anti-browning studies. FOOD CHEMISTRY, 419 (136047). [PMID:37018861] [10.1016/j.foodchem.2023.136047] |
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