Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K140848-25g | 25g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $64.90 | |
K140848-100g | 100g | In stock | $232.90 | |
K140848-250g | 250g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $523.90 | |
K140848-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $551.90 |
Synonyms | AI3-02549 | HSDB 7664 | CS-0032701 | KOJIC ACID (MART.) | 2-HYDROXYMETHYL-5-HYDROXY-.GAMMA.-PYRONE | 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone | HMS502O05 | BIDD:ER0501 | NCGC00168903-01 | InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | NCGC00017325- |
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Specifications & Purity | ≥97% |
Shipped In | Normal |
Product Description | Tyrosinase inhibitor |
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IUPAC Name | 5-hydroxy-2-(hydroxymethyl)pyran-4-one |
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INCHI | InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 |
InChi Key | BEJNERDRQOWKJM-UHFFFAOYSA-N |
Canonical SMILES | C1=C(OC=C(C1=O)O)CO |
Isomeric SMILES | C1=C(OC=C(C1=O)O)CO |
WGK Germany | 3 |
RTECS | UQ0875000 |
PubChem CID | 3840 |
Molecular Weight | 142.11 |
Beilstein | 120895 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2423159 | Certificate of Analysis | Jul 01, 2024 | K140848 |
E2322607 | Certificate of Analysis | May 27, 2023 | K140848 |
H2229644 | Certificate of Analysis | Sep 02, 2022 | K140848 |
H2423020 | Certificate of Analysis | Sep 02, 2022 | K140848 |
E2217150 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217153 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217154 | Certificate of Analysis | May 24, 2022 | K140848 |
E2217162 | Certificate of Analysis | May 24, 2022 | K140848 |
A2219146 | Certificate of Analysis | Feb 15, 2022 | K140848 |
Solubility | Soluble in water, acetone (freely soluble), ethanol (freely soluble), methanol, DMSO, ethyl acetate (slightly soluble), chloroform (slightly soluble), pydidine (slightly soluble), and ether (slightly soluble). Insoluble in benzene. |
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Melt Point(°C) | 154°C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H351:Suspected of causing cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | UQ0875000 |
Merck Index | 5317 |
1. Yilin Lin, Ruifei Wang, Xiaoqing Li, Keren Agyekumwaa Addo, Meimei Fang, Yehui Zhang, Yigang Yu. (2024) Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis. Food Science and Human Wellness, 13 (18): (736). [PMID:28525742] |
2. Jin Chen, Zhuangwei Zhang, Huihui Li, Hongjin Tang. (2023) Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126451). [PMID:37619686] |
3. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI. (2023) Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 51 (100303). [PMID:] |
4. Xiufang Yan, Xiaoyu Ma, Daoxin Dai, Xiaojuan Yan, Xingyan Han, Xijun Bao, Qiufang Xie. (2023) Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism. Journal of Cosmetic Dermatology, 23 (1): (244-255). [PMID:37430475] |
5. Yue Li, Xin-Xin Jiang, Hong-Mei Liu, Xiao-wei Li, Xiao-Jun Luo, Xun Liao, Yan Zhao. (2023) Covalent immobilization of tyrosinase on magnetic multi-walled carbon nanotubes for inhibitor screening. JOURNAL OF SEPARATION SCIENCE, 46 (14): (2300195). [PMID:37232227] |
6. De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao. (2023) Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity. NATURAL PRODUCT RESEARCH, [PMID:37161750] |
7. Min He, Meiyan Fan, Wei Yang, Zhiyun Peng, Guangcheng Wang. (2023) Novel kojic acid-1,2,4-triazine hybrids as anti-tyrosinase agents: Synthesis, biological evaluation, mode of action, and anti-browning studies. FOOD CHEMISTRY, 419 (136047). [PMID:37018861] |
8. Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen. (2023) A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation. JOURNAL OF MOLECULAR STRUCTURE, 1283 (135288). [PMID:] |
9. Qin-Tao Zhou, Peng-Yun Yang, Quan-Yu Yang, Wen-Hui Pang, Xiao-Li Li, Xing-Jie Zhang, Rui-Han Zhang, Wei-Lie Xiao. (2023) Chemical Constituents of the Branches and Leaves of Picrasma chinensis P.Y. Chen and Tyrosinase Inhibiting Activity. CHEMISTRY & BIODIVERSITY, 20 (3): (e202201171). [PMID:36691852] |
10. Wenfu Hou, Yile Lin, Yujie Zhang, Tingting Liu, Juan Du, Yang Yi, Hongxun Wang. (2023) Effects of kojic acid on changes in the microstructure and myofibrillar protein of duck meat during superchilled storage. JOURNAL OF FOOD SCIENCE, 88 (3): (977-987). [PMID:36650660] |
11. Dechan Lu, Qun Zhang, Zufang Huang, Yudong Lu, Shangyuan Feng, Ruiyun You, Minling Li, Shaoqin Zhang. (2022) Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard. COLLOIDS AND SURFACES B-BIOINTERFACES, 217 (112645). [PMID:35780613] |
12. Yue Zheng, Lei Zhao, Junjie Yi. (2022) Phytochemical Characterization and Antioxidant and Enzyme Inhibitory Activities of Different Parts of Prinsepia utilis Royle. JOURNAL OF FOOD QUALITY, 2022 (9739851). [PMID:] |
13. Zhao Yan, Hu Jin-Jie, Bai Xiao-Lin, Liu Hao-Peng, Qi Xu-Wei, Liao Xun. (2022) Fast screening of tyrosinase inhibitors from traditional Chinese medicinal plants by ligand fishing in combination with in situ fluorescent assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (6): (2265-2273). [PMID:34982177] |
14. Xiang Liu, Jinqiu Rao, Kai Wang, Meijun Wang, Tie Yao, Feng Qiu. (2021) Highly Potent Inhibition of Tyrosinase by Mulberrosides and the Inhibitory Mechanism in Vitro. CHEMISTRY & BIODIVERSITY, 19 (1): (e202100740). [PMID:34752017] |
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |
1. Yilin Lin, Ruifei Wang, Xiaoqing Li, Keren Agyekumwaa Addo, Meimei Fang, Yehui Zhang, Yigang Yu. (2024) Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis. Food Science and Human Wellness, 13 (18): (736). [PMID:28525742] |
2. Jin Chen, Zhuangwei Zhang, Huihui Li, Hongjin Tang. (2023) Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126451). [PMID:37619686] |
3. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI. (2023) Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 51 (100303). [PMID:] |
4. Xiufang Yan, Xiaoyu Ma, Daoxin Dai, Xiaojuan Yan, Xingyan Han, Xijun Bao, Qiufang Xie. (2023) Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism. Journal of Cosmetic Dermatology, 23 (1): (244-255). [PMID:37430475] |
5. Yue Li, Xin-Xin Jiang, Hong-Mei Liu, Xiao-wei Li, Xiao-Jun Luo, Xun Liao, Yan Zhao. (2023) Covalent immobilization of tyrosinase on magnetic multi-walled carbon nanotubes for inhibitor screening. JOURNAL OF SEPARATION SCIENCE, 46 (14): (2300195). [PMID:37232227] |
6. De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao. (2023) Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity. NATURAL PRODUCT RESEARCH, [PMID:37161750] |
7. Min He, Meiyan Fan, Wei Yang, Zhiyun Peng, Guangcheng Wang. (2023) Novel kojic acid-1,2,4-triazine hybrids as anti-tyrosinase agents: Synthesis, biological evaluation, mode of action, and anti-browning studies. FOOD CHEMISTRY, 419 (136047). [PMID:37018861] |
8. Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen. (2023) A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation. JOURNAL OF MOLECULAR STRUCTURE, 1283 (135288). [PMID:] |
9. Qin-Tao Zhou, Peng-Yun Yang, Quan-Yu Yang, Wen-Hui Pang, Xiao-Li Li, Xing-Jie Zhang, Rui-Han Zhang, Wei-Lie Xiao. (2023) Chemical Constituents of the Branches and Leaves of Picrasma chinensis P.Y. Chen and Tyrosinase Inhibiting Activity. CHEMISTRY & BIODIVERSITY, 20 (3): (e202201171). [PMID:36691852] |
10. Wenfu Hou, Yile Lin, Yujie Zhang, Tingting Liu, Juan Du, Yang Yi, Hongxun Wang. (2023) Effects of kojic acid on changes in the microstructure and myofibrillar protein of duck meat during superchilled storage. JOURNAL OF FOOD SCIENCE, 88 (3): (977-987). [PMID:36650660] |
11. Dechan Lu, Qun Zhang, Zufang Huang, Yudong Lu, Shangyuan Feng, Ruiyun You, Minling Li, Shaoqin Zhang. (2022) Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard. COLLOIDS AND SURFACES B-BIOINTERFACES, 217 (112645). [PMID:35780613] |
12. Yue Zheng, Lei Zhao, Junjie Yi. (2022) Phytochemical Characterization and Antioxidant and Enzyme Inhibitory Activities of Different Parts of Prinsepia utilis Royle. JOURNAL OF FOOD QUALITY, 2022 (9739851). [PMID:] |
13. Zhao Yan, Hu Jin-Jie, Bai Xiao-Lin, Liu Hao-Peng, Qi Xu-Wei, Liao Xun. (2022) Fast screening of tyrosinase inhibitors from traditional Chinese medicinal plants by ligand fishing in combination with in situ fluorescent assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (6): (2265-2273). [PMID:34982177] |
14. Xiang Liu, Jinqiu Rao, Kai Wang, Meijun Wang, Tie Yao, Feng Qiu. (2021) Highly Potent Inhibition of Tyrosinase by Mulberrosides and the Inhibitory Mechanism in Vitro. CHEMISTRY & BIODIVERSITY, 19 (1): (e202100740). [PMID:34752017] |
15. Lilin Tang,Wenpeng Zhang,Haiyan Zhao,Zilin Chen. (2015-06-04) Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.. Journal of separation science, 38 ((16)): (2887-2892). [PMID:26037533] |