KPNA2 Mouse mAb - Primary antibody, specific to KPNA2, Mouse IgG1

    Application:
  • IHC
  • WB
Features and benefits
  • Host species: Mouse
  • Species reactivity(Reacts with): Human,Mouse,Pig,Rat
  • Isotype: Mouse IgG1
  • Clone Number: C8
  • Conjugation: Unconjugated
Item Number
Ab112361
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab112361-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$86.90
Ab112361-50μl
50μl
In stock
$259.90
Ab112361-100μl
100μl
In stock
$389.90
Ab112361-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90

mAb(C8); Mouse anti Human KPNA2 Antibody; WB, IHC; Unconjugated

Basic Description

Product NameKPNA2 Mouse mAb - Primary antibody, specific to KPNA2, Mouse IgG1
SynonymsAnti-KPNA2 antibody | IMA1_HUMAN antibody | Importin alpha 1 antibody | Importin alpha 2 antibody | Importin alpha 2 subunit antibody | Importin alpha P1 antibody | Importin subunit alpha-1 antibody | IPO A1 antibody | IPOA 1 antibody | IPOA1 antibody | K
Specifications & PurityExactAb™, Validated, Carrier Free, High performance, Lot by Lot
Host speciesMouse
SpecificityKPNA2
ImmunogenRecombinant KPNa2 expressed in E.coli (AA 157-412).
Positive ControlWB: Jurkat, HEK293, HeLa, Hep G2, A549, NIH/3T3 and C6 cell lysates. IHC: Human kidney tissue.
ConjugationUnconjugated
GradeCarrier Free, ExactAb™, High Performance, Validated
Note20μl卖完停产,不再备货
Product Description

Mouse anti Human KPNA2 Antibody, Monoclonal (C8), could be used for WB, IHC and so on.
Application:
WB: 0.01-3µg/mL
IHC : 5-20µg/mL
Protein Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Product Properties

IsotypeMouse IgG1
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A + Protein G purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

[Ab112361] KPNA2 Mouse mAb - Western Blot
All lanes: KPNA2 Mouse mAb (Ab112361) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 58 kDa
Observed band size: 63 kDa
Exposure time: 6.6 s

KPNA2 Mouse mAb (Ab112361) - IHC
DAB staining on IHC
Sample: Human Kidney Tissue
Primary Ab: 10 µg/mL KPNA2 Mouse mAb (Ab112361)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.

Associated Targets(Human)

KPNA2 Tbio Importin subunit alpha-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Application

ApplicationDilution info
WB

0.01-3 µg/mL

IHC

5-20 µg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1101585Certificate of AnalysisNov 08, 2023 Ab112361
ZJ23F1101584Certificate of AnalysisNov 08, 2023 Ab112361

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