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KRCA 0008 - 98%, high purity , CAS No.1472795-20-2

  • ≥98%
Item Number
K287624
Grouped product items
SKUSizeAvailabilityPrice Qty
K287624-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$32.90
K287624-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$191.90
K287624-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$104.90
K287624-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$550.90
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Potent Ack1 and ALK dual inhibitor

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50= 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

ALK Tclin ALK tyrosine kinase receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALK Tclin ALK tyrosine kinase receptor (7132 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H3122 (436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-[4-[4-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
INCHI InChI=1S/C30H37ClN8O4/c1-20(40)36-9-13-38(14-10-36)22-5-7-25(27(17-22)42-3)33-29-24(31)19-32-30(35-29)34-26-8-6-23(18-28(26)43-4)39-15-11-37(12-16-39)21(2)41/h5-8,17-19H,9-16H2,1-4H3,(H2,32,33,34,35)
InChi Key TXDIRJCYNAWBOS-UHFFFAOYSA-N
Canonical SMILES CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC(=NC=C3Cl)NC4=C(C=C(C=C4)N5CCN(CC5)C(=O)C)OC)OC
Isomeric SMILES CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC(=NC=C3Cl)NC4=C(C=C(C=C4)N5CCN(CC5)C(=O)C)OC)OC
PubChem CID 72547474
Molecular Weight 609.12

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
A2420252Certificate of AnalysisDec 21, 2023 K287624
A2420253Certificate of AnalysisDec 21, 2023 K287624
A2420254Certificate of AnalysisDec 21, 2023 K287624
A2420255Certificate of AnalysisDec 21, 2023 K287624

Chemical and Physical Properties

SolubilitySolvent:1eq. HCl, Max Conc. mg/mL: 60.91, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 60.91, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 60.91, Max Conc. mM: 100

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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