KT182 - ≥99.0%, high purity , CAS No.1402612-62-7

  • ≥99%
Item Number
K649966
Grouped product items
SKUSizeAvailabilityPrice Qty
K649966-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$190.90
K649966-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$290.90
View related series
MAGL Metabolic Enzyme/Protease

Basic Description

SynonymsHY-120177 | KT182, >=98% (HPLC) | SCHEMBL13192356 | BDBM50010335 | (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone | MLS004256823 | CGC61262 | CS-0077095 | AKOS027263749 | SMR003081898 | [4-[4-[3-(hydro
Specifications & Purity≥99%
Biochemical and Physiological MechanismsKT182 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6) , with an IC 50 of 0.24 nM in Neuro2A cells.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

KT182 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6) , with an IC 50 of 0.24 nM in Neuro2A cells

Form:Solid

IC50& Target:IC50: 0.24 nM (ABHD6 in Neuro2A cells)

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRCP Tchem Lysosomal Pro-X carboxypeptidase (567 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAT Tclin Tissue-type plasminogen activator (1057 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FASN Tchem Fatty acid synthase (3390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCEH1 Tchem Neutral cholesterol ester hydrolase 1 (158 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABHD12 Tchem Monoacylglycerol lipase ABHD12 (195 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DAGLB Tchem Sn1-specific diacylglycerol lipase beta (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSA Tchem Lysosomal protective protein (919 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RBBP9 Tchem Putative hydrolase RBBP9 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPME1 Tchem Protein phosphatase methylesterase 1 (52 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LYPLA1 Tchem Acyl-protein thioesterase 1 (16 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEH Tchem Acylamino-acid-releasing enzyme (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LYPLA2 Tchem Acyl-protein thioesterase 2 (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PNPLA8 Tbio Calcium-independent phospholipase A2-gamma (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PNPLA6 Tbio Neuropathy target esterase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESD Tchem S-formylglutathione hydrolase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCPEP1 Tbio Retinoid-inducible serine carboxypeptidase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LYPLAL1 Tbio Lysophospholipase-like protein 1 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACOT2 Tbio Acyl-coenzyme A thioesterase 2, mitochondrial (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACOT1 Tbio Acyl-coenzyme A thioesterase 1 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPT2 Tbio Lysosomal thioesterase PPT2 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PREP Prolyl endopeptidase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Faah Anandamide amidohydrolase (3907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tpp2 Tripeptidyl-peptidase 2 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd16a Protein BAT5 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lipe Hormone-sensitive lipase (209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd6 Monoacylglycerol lipase ABHD6 (221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd11 Abhydrolase domain-containing protein 11 (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pafah2 Platelet-activating factor acetylhydrolase 2, cytoplasmic (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd10 Mycophenolic acid acyl-glucuronide esterase, mitochondrial (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pafah1b2 Platelet-activating factor acetylhydrolase IB subunit beta (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pafah1b3 Platelet-activating factor acetylhydrolase IB subunit gamma (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dpp9 Dipeptidyl peptidase 9 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mzb1 Marginal zone B- and B1-cell-specific protein (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lonp1 Lon protease homolog, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd13 Alpha/beta hydrolase domain-containing protein 13 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Qrsl1 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ddhd2 Phospholipase DDHD2 (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pla2g15 Group XV phospholipase A2 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lactb Serine beta-lactamase-like protein LACTB, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pnpla7 Patatin-like phospholipase domain-containing protein 7 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Serhl Serine hydrolase-like protein (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dpp7 Dipeptidyl peptidase 2 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Parl Presenilins-associated rhomboid-like protein, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pla2g6 85/88 kDa calcium-independent phospholipase A2 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ddhd1 Phospholipase DDHD1 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pgap1 GPI inositol-deacylase (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Htra2 Serine protease HTRA2, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd5 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone
INCHI InChI=1S/C27H26N4O2/c32-19-20-7-6-10-24(17-20)21-12-14-22(15-13-21)25-18-31(29-28-25)27(33)30-16-5-4-11-26(30)23-8-2-1-3-9-23/h1-3,6-10,12-15,17-18,26,32H,4-5,11,16,19H2
InChi Key GICNKPZHUCVFNM-UHFFFAOYSA-N
Canonical SMILES C1CCN(C(C1)C2=CC=CC=C2)C(=O)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC(=C5)CO
Isomeric SMILES C1CCN(C(C1)C2=CC=CC=C2)C(=O)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC(=C5)CO
PubChem CID 53364491
Molecular Weight 438.52

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 100 mg/mL (228.04 mM; Need ultrasonic) Ethanol : 11 mg/mL (25.08 mM; Need ultrasonic and warming)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H413:May cause long lasting harmful effects to aquatic life

H302:Harmful if swallowed

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators