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KU 60019 - ≥98%, high purity , CAS No.925701-46-8
Basic Description Synonyms KU-60019, >=98% (HPLC) | SW219699-1 | 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide | NCGC00229735-01 | BDBM50059640 | AC-32798 | 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description KU 60019 is a potent inhibitor of ATM kinase. Against a panel of 229 protein kinases, it exhibits little to no nonspecific target effects, displaying similar target selectivity to KU 55933. KU 60019 has also been shown to Inhibit invasion and migration of human glioma cells|in vitro|.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide INCHI InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ InChi Key SCELLOWTHJGVIC-BGYRXZFFSA-N Canonical SMILES CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6 Isomeric SMILES C[C@@H]1CN(C[C@@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6 PubChem CID 15953870 Molecular Weight 547.67
Chemical and Physical Properties Solubility Soluble in DMSO (100 mM), and ethanol (100 mM). Refractive Index n20D1.65 (Predicted) Boil Point(°C) 786.6° C at 760 mmHg (Predicted)
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