KV-37 , CAS No.K611364, Inhibitor of AKR1C3

Item Number

K611364

Grouped product items
SKU	Size	Availability	Price	Qty
K611364-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
K611364-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	AKR1C3 inhibitor KV-37 \| 1954693-22-1 \| CHEMBL4470997 \| KV-37 \| SCHEMBL20472116 \| GTPL10262 \| DTXSID701122793 \| KV 37 \| BDBM50509753 \| BK168413 \| (E)-3-[4-(3-methylbut-2-enyl)-3-(3-phenylpropanoylamino)phenyl]prop-2-enoic acid \| (2E)-3-[4-(3-Methyl-2-buten-1-yl)-3-[(1-oxo-3-ph
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of AKR1C3

Associated Targets(Human)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (5 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THP-1 (11052 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKR1C3 Tchem Aldo-keto-reductase family 1 member C3 (1414 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (639 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KG-1a (249 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(E)-3-[4-(3-methylbut-2-enyl)-3-(3-phenylpropanoylamino)phenyl]prop-2-enoic acid
INCHI	InChI=1S/C23H25NO3/c1-17(2)8-12-20-13-9-19(11-15-23(26)27)16-21(20)24-22(25)14-10-18-6-4-3-5-7-18/h3-9,11,13,15-16H,10,12,14H2,1-2H3,(H,24,25)(H,26,27)/b15-11+
InChi Key	SMYHHZFAWOLAAX-RVDMUPIBSA-N
Canonical SMILES	O=C(Nc1cc(/C=C/C(=O)O)ccc1CC=C(C)C)CCc1ccccc1
Isomeric SMILES	CC(=CCC1=C(C=C(C=C1)/C=C/C(=O)O)NC(=O)CCC2=CC=CC=C2)C
PubChem CID	134817174

References

1. Verma K, Gupta N, Zang T, Wangtrakluldee P, Srivastava SK, Penning TM, Trippier PC. (2018) AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells.. Mol Cancer Ther, 17 (9): (1833-1845). [PMID:29891491]

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Basic Description