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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K287280-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $123.90 | |
K287280-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $179.90 | |
K287280-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $483.90 | |
K287280-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $499.90 | |
K287280-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $739.90 |
High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
Synonyms | (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile | KYP-2047 |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S)-1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile |
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INCHI | InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1 |
InChi Key | SPXFAUXQZWJGCJ-ROUUACIJSA-N |
Canonical SMILES | C1CC(N(C1)C(=O)C2CCCN2C(=O)CCCC3=CC=CC=C3)C#N |
Isomeric SMILES | C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N |
WGK Germany | 3 |
PubChem CID | 11198569 |
Molecular Weight | 339.44 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2429263 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429264 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429265 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429266 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429267 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429268 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429269 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429296 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429297 | Certificate of Analysis | Apr 23, 2024 | K287280 |
G2429298 | Certificate of Analysis | Apr 23, 2024 | K287280 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 33.94, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 16.97, Max Conc. mM: 50 |
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Hazard Statements | H319:Causes serious eye irritation |
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Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
WGK Germany | 3 |
RIDADR | NONHforallmodesoftransport |