KYP 2047 - ≥98%(HPLC), high purity , CAS No.796874-99-2

  • ≥98%(HPLC)
Item Number
K287280
Grouped product items
SKUSizeAvailabilityPrice Qty
K287280-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$123.90
K287280-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$179.90
K287280-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$483.90
K287280-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$499.90
K287280-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$739.90

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

Basic Description

Synonyms(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile | KYP-2047
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsKYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

PREP Tchem Prolyl endopeptidase (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DPP7 Tchem Dipeptidyl peptidase II (2000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FAP Tchem Fibroblast activation protein alpha (827 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

DPP4 Dipeptidyl peptidase IV (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PREP Prolyl endopeptidase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
INCHI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
InChi Key SPXFAUXQZWJGCJ-ROUUACIJSA-N
Canonical SMILES C1CC(N(C1)C(=O)C2CCCN2C(=O)CCCC3=CC=CC=C3)C#N
Isomeric SMILES C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N
WGK Germany 3
PubChem CID 11198569
Molecular Weight 339.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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10 results found

Lot NumberCertificate TypeDateItem
G2429263Certificate of AnalysisApr 23, 2024 K287280
G2429264Certificate of AnalysisApr 23, 2024 K287280
G2429265Certificate of AnalysisApr 23, 2024 K287280
G2429266Certificate of AnalysisApr 23, 2024 K287280
G2429267Certificate of AnalysisApr 23, 2024 K287280
G2429268Certificate of AnalysisApr 23, 2024 K287280
G2429269Certificate of AnalysisApr 23, 2024 K287280
G2429296Certificate of AnalysisApr 23, 2024 K287280
G2429297Certificate of AnalysisApr 23, 2024 K287280
G2429298Certificate of AnalysisApr 23, 2024 K287280

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 33.94, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 16.97, Max Conc. mM: 50

Safety and Hazards(GHS)

Hazard Statements

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators