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L-365,260 - ≥99%(HPLC), high purity , CAS No.118101-09-0, Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

3 Citations

Moligand™

≥99%(HPLC)

CAS#: 118101-09-0
Formula: C₂₄H₂₂N₄O₂
Molecular Weight: 398.46
PubChem CID: 5311201

Item Number

L287661

Grouped product items
SKU	Size	Availability	Price	Qty
L287661-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$157.90
L287661-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$256.90

Selective CCK2antagonist

View related series

CCK1 receptor Antagonist CCK2 receptor Antagonist Cholecystokinin Receptor GPCR/G Protein Neuronal Signaling

Basic Description

Synonyms	UNII-370JHF4586 \| (R)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)-urea \| MS-26737 \| CHEBI:79548 \| PDSP1_000921 \| SCHEMBL5931098 \| L365260 \| L-365260 \| L 365,260 \| Urea, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Selective cholecystokinin receptor 2 (CCK2) antagonist (IC50values are 2 and 280 nM at CCK2and CCK1receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine,α- andβadrenergic, histamine, angiotensin
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

Associated Targets(Human)

CCKAR Tclin Cholecystokinin receptor type A (1 Activities)

Discover Target: CCKAR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCKBR Tclin Gastrin/cholecystokinin type B receptor (35 Activities)

Discover Target: CCKBR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[(3R)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea
INCHI	InChI=1S/C24H22N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
InChi Key	KDFQABSFVYLGPM-QFIPXVFZSA-N
Canonical SMILES	CC1=CC(=CC=C1)NC(=O)NC2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)C
Isomeric SMILES	CC1=CC(=CC=C1)NC(=O)N[C@H]2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)C
PubChem CID	5311201
Molecular Weight	398.46

Database links

PubChem CID	104929
ChEMBL Ligand	CHEMBL289498
CAS Registry No.	118101-09-0
GPCRdb Ligand	L-365260

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
J2225624	Certificate of Analysis	Oct 10, 2022	L287661
J2225625	Certificate of Analysis	Oct 10, 2022	L287661

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 39.85, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 39.85, Max Conc. mM: 100
Sensitivity	light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
RIDADR	UN2811-class6.1-PG3-EHS-Toxicsolids，organic，n.o.s.，HI:all

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yuanyuan Cao, Shuyi Shan, Yitong Lu, Jialu Luo, Yilin Li, Rongzhang Hao. (2023) Tuning toxic properties of polyethylene glycol-based deep eutectic solvents for achieving greener solvents. JOURNAL OF MOLECULAR LIQUIDS, 369 (120879). [PMID:] [10.1016/j.molliq.2022.120879]
2. Zhuang He, Yunqiu Zhang, Jiapei Lv, Shuxing Zhou, Jianrui Niu, Zaixing Li, Xinzhong Wang, Thomas Wågberg, Guangzhi Hu. (2022) Microwave-assisted synthesis of amorphous cobalt nanoparticle decorated N-doped biochar for highly efficient degradation of sulfamethazine via peroxymonosulfate activation. Journal of Water Process Engineering, 50 (103226). [PMID:] [10.1016/j.jwpe.2022.103226]
3. Y. Ma, A.Y. Chen, X.F. Xie, X.Y. Wang, D. Wang, P. Wang, H.J. Li, J.H. Yang, Y. Li. (2019) Doping effect and fluorescence quenching mechanism of N-doped graphene quantum dots in the detection of dopamine. TALANTA, 196 (563). [PMID:30683406] [10.1016/j.talanta.2019.01.001]

References

1. Yuanyuan Cao, Shuyi Shan, Yitong Lu, Jialu Luo, Yilin Li, Rongzhang Hao. (2023) Tuning toxic properties of polyethylene glycol-based deep eutectic solvents for achieving greener solvents. JOURNAL OF MOLECULAR LIQUIDS, 369 (120879). [PMID:] [10.1016/j.molliq.2022.120879]
2. Zhuang He, Yunqiu Zhang, Jiapei Lv, Shuxing Zhou, Jianrui Niu, Zaixing Li, Xinzhong Wang, Thomas Wågberg, Guangzhi Hu. (2022) Microwave-assisted synthesis of amorphous cobalt nanoparticle decorated N-doped biochar for highly efficient degradation of sulfamethazine via peroxymonosulfate activation. Journal of Water Process Engineering, 50 (103226). [PMID:] [10.1016/j.jwpe.2022.103226]
3. Y. Ma, A.Y. Chen, X.F. Xie, X.Y. Wang, D. Wang, P. Wang, H.J. Li, J.H. Yang, Y. Li. (2019) Doping effect and fluorescence quenching mechanism of N-doped graphene quantum dots in the detection of dopamine. TALANTA, 196 (563). [PMID:30683406] [10.1016/j.talanta.2019.01.001]

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