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L-685,458 - ≥98%, high purity , CAS No.292632-98-5
Potent, selective and non-competitive γ-secretase inhibitor
Basic Description Synonyms 292632-98-5 | l-685,458 | L-685458 | L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl- | L685458 | CHEMBL302004 | CHEBI:74921 | tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phe Specifications & Purity ≥98% Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Product Description Store at -20°C (desiccating conditions).
application
L-685,458 has been used to attenuate Notch signalling in ovary culture. It has also been used to analyze the specificity of the γ-secretase activity in brain tissue samples.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate INCHI InChI=1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32+,33+,34-/m1/s1 InChi Key MURCDOXDAHPNRQ-ZJKZPDEISA-N Canonical SMILES CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O Isomeric SMILES CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)C[C@H]([C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O PubChem CID 5479543 Molecular Weight 672.85
Chemical and Physical Properties Solubility Supplied in DMSO (1 mM),Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) Melt Point(°C) 209-211°C
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K2218518