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L-689,560 - ≥99%(HPLC), high purity , CAS No.139051-78-8, Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D

Moligand™
≥99%(HPLC)

CAS#: 139051-78-8
Formula: C₁₇H₁₅Cl₂N₃O₃
Molecular Weight: 380.23
PubChem CID: 4267713

Item Number

L287337

Grouped product items
SKU	Size	Availability	Price
L287337-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$44.90
L287337-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$157.90
L287337-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$201.90
L287337-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$588.90
L287337-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$846.90
L287337-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,485.90

Highly potent NMDA antagonist

View related series

GluN1 Antagonist GluN2A Antagonist GluN2B Antagonist GluN2C Antagonist GluN2D Antagonist

Basic Description

Synonyms	L-689,560\|139051-78-8\|4-[[anilino(oxo)methyl]amino]-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid\|L-689560\|CHEMBL512824\|SCHEMBL1993880\|CHEBI:91612\|DTXSID90874898\|HMS3266P09\|AKOS030228809\|5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydr
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Very potent antagonist at the glycine-NMDA site.
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D
Product Description	L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits GluN1 glycine binding sites. L-689560 is widely used as a radiolabeling ligand in binding studies, as well as to study the role of NMDA receptors in normal nervous system processes and diseases

Associated Targets

GPRIN1 Tbio G protein-regulated inducer of neurite outgrowth 1 0 Activities

Discover Target: GPRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 1 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A 0 Activities

Discover Target: GRIN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 0 Activities

Discover Target: GRIN2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Discover Target: GRIN2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D 0 Activities

Discover Target: GRIN2D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
INCHI	InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)
InChi Key	UCKHICKHGAOGAP-UHFFFAOYSA-N
Canonical SMILES	C1C(C2=C(C=C(C=C2Cl)Cl)NC1C(=O)O)NC(=O)NC3=CC=CC=C3
Isomeric SMILES	C1C(C2=C(C=C(C=C2Cl)Cl)NC1C(=O)O)NC(=O)NC3=CC=CC=C3
PubChem CID	4267713
Molecular Weight	380.23

PubChem CID

121918

CAS Registry No.

139051-78-8

ChEBI

CHEBI:250344

References

1. Leeson PD, Carling RW, Moore KW, Moseley AM, Smith JD, Stevenson G, Chan T, Baker R, Foster AC, Grimwood S et al.. (1992) 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.. J Med Chem, 35 (11): (1954-68). [PMID:1534584]

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