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L-739,750 , CAS No.160141-08-2, Inhibitor of farnesyltransferase; CAAX box; beta

CAS#: 160141-08-2
PubChem CID: 5287548

Item Number

L611407

Grouped product items
SKU	Size	Availability	Price	Qty
L611407-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611407-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,891.90

View related series

farnesyltransferase，CAAX box，beta Inhibitor

Synonyms

L 739750

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of farnesyltransferase; CAAX box; beta

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-[(2S,3S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoic acid
INCHI	InChI=1S/C23H39N3O6S2/c1-4-16(2)20(25-13-18(24)15-33)14-32-21(12-17-8-6-5-7-9-17)22(27)26-19(23(28)29)10-11-34(3,30)31/h5-9,16,18-21,25,33H,4,10-15,24H2,1-3H3,(H,26,27)(H,28,29)/t16-,18+,19-,20+,21-/m0/s1
InChi Key	SIEXHGZWGJLLAC-OSTWSGHESA-N
Canonical SMILES	CC[C@@H]([C@H](NC[C@H](CS)N)CO[C@H](C(=O)N[C@H](C(=O)O)CCS(=O)(=O)C)Cc1ccccc1)C
Isomeric SMILES	CC[C@H](C)[C@@H](CO[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCS(=O)(=O)C)C(=O)O)NC[C@H](CS)N
PubChem CID	5287548

PubChem CID

CAS Registry No.

RCSB PDB Ligand

Reactome Reaction

Reactome Drug

References

1. Kohl NE, Wilson FR, Mosser SD, Giuliani E, deSolms SJ, Conner MW, Anthony NJ, Holtz WJ, Gomez RP, Lee TJ et al.. (1994) Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.. Proc Natl Acad Sci USA, 91 (19): (9141-5). [PMID:8090782] [10.1021/op500134e]
2. Downward J. (2003) Targeting RAS signalling pathways in cancer therapy.. Nat Rev Cancer, 3 (1): (11-22). [PMID:12509763] [10.1021/op500134e]

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L-739,750 , CAS No.160141-08-2, Inhibitor of farnesyltransferase; CAAX box; beta

Basic Description

Associated Targets(Human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

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References

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