L-741,626 - 97%, high purity , CAS No.81226-60-0, Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of D 2 receptor

Item Number

L275040

• Synonyms: A19235 | BDBM50050467 | CCG-204827 | A13694 | GTPL177 | L741,626 | L-741,626 | PDSP2_001399 | SPCIYGNTAMCTRO-UHFFFAOYSA-N | NCGC00015591-05 | NCGC00024932-02 | NCGC00024932-03 | 4-Piperidinol, 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)- | Lopac-L-135 | 3-
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: Potent and selective D 2 antagonist (K i values are 2.4, 100 and 220 nM at D 2 , D 3 and D 4 receptors, respectively). Centrally active following in vivo systemic administration.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of D 2 receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Application：

L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.